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Copyright (c) 2025 Sarmad Qassim Mohammad, Hussam Sami Awayid, Sinda Zarrouk-Mahjoub, Idriss Saleh Jallil
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Molecular Identification of erm A and erm B, erm C genes in methicillin-resistant Staphylococcus aureus isolates from burns Patients and their association with multidrug resistance
Corresponding Author(s) : Sarmad Qassim Mohammad
Cellular and Molecular Biology,
Vol. 71 No. 5: Issue 5
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant hospital-acquired pathogen, particularly concerning in burn patients due to its multidrug resistance. This study aimed to assess the antibiotic sensitivity profile and identify the presence of erm genes (ermA, ermB, and ermC) associated with erythromycin resistance in MRSA isolates from burn patients. A total of 80 S. aureus isolates were collected from burn cases, with initial diagnoses performed using conventional culture and microscopic methods. MRSA isolates were confirmed using chromogenic agar media, and antibiotic susceptibility was determined via the disc diffusion method. Polymerase chain reaction (PCR) was employed to detect the erm genes responsible for macrolide resistance. Among 80 samples, 40 were identified as S. aureus, of which 18 were confirmed as MRSA. PCR analysis revealed the prevalence of ermA, ermB, and ermC genes at rates of 12%, 33%, and 11%, respectively. All MRSA isolates exhibited multidrug resistance to antibiotics, highlighting the challenge of treating infections in burn patients. This study underscores the critical need for molecular characterization of MRSA strains to inform effective therapeutic strategies and control their spread in burn wards.
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