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Copyright (c) 2025 Alper Özdeş, Tuğçe Kaymaz, Ahmet Karakeçi, Ferit Gürsu; Fatih Osmanlıoğlu
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The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Levels of Trimethylamine N-Oxide and Lipopolysaccharides in Vascular and ıdiopathic erectile dysfunction
Corresponding Author(s) : Ahmet Alper Özdeş
Cellular and Molecular Biology,
Vol. 71 No. 6: Issue 6
Abstract
The gut microbiota influences endothelial dysfunction through metabolites like lipopolysaccharides (LPS) and trimethylamine-N-oxide (TMAO), affecting cardiovascular health and contributing to atherosclerosis and hypertension development. We evaluated TMAO and LPS levels in patients with vascular and idiopathic erectile dysfunction (ED). In this study of 151 participants (50 vascular ED, 50 idiopathic ED, 51 healthy controls), patients were categorized using comprehensive clinical assessment including International Index of Erectile Function (IIEF), laboratory tests, and imaging methods. While age (mean 55.15±7.17 years) and TMAO levels showed no significant differences between groups (p>0.05), LPS levels were significantly elevated in the vascular ED group (497.36±87.83) compared to idiopathic ED (430.62±69.72) and control groups (436.98±105.37) (p<0.05). These findings suggest that gut microbiota metabolites, particularly LPS, play a significant role in ED pathophysiology through endothelial dysfunction. Regulating gut microbiota may serve as both a protective factor against ED development and a potential treatment option for existing cases. Further comprehensive studies are warranted to explore these therapeutic possibilities.
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