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Quercetin modulates Na(+)/K(+) ATPase and sodium hydrogen exchanger in type 2 diabetic erythrocytes
Corresponding Author(s) : N. Mishra
Cellular and Molecular Biology,
Vol. 58 No. 1: Frontiers in biological sciences issue
Abstract
Quercetin has been reported to possess many important biological properties. We undertook in vitro studies to examine the effect of quercetin on erythrocyte Na+/K+ ATPase and sodium hydrogen exchanger (NHE) activity in normal and type 2 diabetic subjects. A significant (p<0.02) increase in the activities of Na+/K+ ATPase and a decrease (p< 0.01) in NHE were observed in type 2 diabetic subjects compared to normal. In vitro treatment with quercetin caused inhibition of both Na+/K + ATPase and NHE. The inhibitory effect of quercetin was concentration dependent. The effect of quercetin on Na+/K+ ATPase and NHE may be explained due to a direct effect of this compound on plasma membrane leading to a change in membrane fluidity. The data obtained in this study may help to explain the anti-diabetic and anti-carcinogenic role of quercetin.
Keywords
Diabetes
erythrocytes
quercetin
Na /K ATPase
NHE.
Mishra, N., & Rizvi, S. I. (2012). Quercetin modulates Na(+)/K(+) ATPase and sodium hydrogen exchanger in type 2 diabetic erythrocytes. Cellular and Molecular Biology, 58(1), 148–152. Retrieved from https://mail.cellmolbiol.org/index.php/CMB/article/view/590
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