The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.
Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes.
Corresponding Author(s) : Y. Yang
yyang@sookmyung.ac.kr
Cellular and Molecular Biology,
Vol. 56 No. 3: General Papers
Abstract
Asarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-α and peroxisome proliferator activated receptor-γ, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPARγ and C/EBPα and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity.
Keywords
C/EBPα
PPARγ
Adiponectin
Asarone
Hormone-sensitive lipase
Lee, S. H., Kim, K.-Y., Ryu, S. Y., Yoon, Y., Hahm, D.-H., Kang, S. A., Cho, S. H., Lim, J.-S., Moon, E.-Y., Yoon, S. R., Lee, H. G., Yoon, D. Y., & Yang, Y. (2010). Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes. Cellular and Molecular Biology, 56(3), 1215–22. Retrieved from https://mail.cellmolbiol.org/index.php/CMB/article/view/967
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX