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The trypanocidal activity of the alkaloid oliverine involves inhibition of DNA synthesis
Corresponding Author(s) : C. R. Pungitore
crpungi@unsl.edu.ar
Cellular and Molecular Biology,
Vol. 56 No. 3: General Papers
Abstract
The Trypanosoma cruzi parasite is an etiologic agent of the American trypanosomiasis called Chagas disease. This pathology affects more than 24 million persons and represents one of the most important public health problems in Latin America. Taking into account this, it is necessary the search of new antitrypanosomal agents that show a major level of efficacy and minor indexes of toxicity in affected patients. Vast source of them are the natural products from plants with enormous structural diversity. A particular type of these compounds is represented by aporphinoid alkaloids. In our experiments, anonaine (2), oliverine (3) and guatterine (5) displayed antitrypanosomal activity. The compound 3 showed the most important activity with an IC50 = 12.00 ± 0.36 μM. Its mechanism of action may include inhibition of DNA synthesis.
Keywords
Aporphinoid alkaloids
Trypanosoma cruzi
natural products
oliverine
biological activity.
Garro, H. A., Juri Ayub, M., Nieto, M., Lucero Estrada, C., Pungitore, C. R., & Tonn, C. E. (2010). The trypanocidal activity of the alkaloid oliverine involves inhibition of DNA synthesis. Cellular and Molecular Biology, 56(3), 1318–23. Retrieved from https://mail.cellmolbiol.org/index.php/CMB/article/view/978
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