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Vol. 63 No. 8: Issue 8

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Association between platelet to lymphocyte ratio (PLR) and overall survival (OS) of hepatocellular carcinoma (HCC): A meta-analysis

https://doi.org/10.14715/cmb/2017.63.8.7
D-H. Hu
Department of hepatopathy, Hubei Zhongshan Hospital, No. 26 Zhongshan Avenue, Wuhan 430033, Hubei, China
S-M. Yu
Department of hepatopathy, Hubei Zhongshan Hospital, No. 26 Zhongshan Avenue, Wuhan 430033, Hubei, China

Corresponding Author(s) : S-M. Yu

jihbm7412839@163.com

Cellular and Molecular Biology, Vol. 63 No. 8: Issue 8

Abstract

Some studies investigated the association between platelet-to-lymphocyte ratio (PLR) and the survival of hepatocellular carcinoma (HCC). However, the results remained inconclusive. Thus, we performed this meta-analysis. Published studies were searched in PubMed and EMBASE. The strength of association was assessed by calculating odds ratios (OR) and 95% confidence interval (CI). In total, 6 studies with 1446 HCC patients were included in this meta-analysis. HCC with higher PLR showed an increased death risk (OR = 1.59; 95%CI, 1.15–2.20; P < 0.0001). However, the heterogeneity was high (I2=89.2%). When the study by Li et al. was excluded, the heterogeneity decreased (I2=20%). Further, the result was still positive (OR = 1.70; 95%CI, 1.42–2.04; P < 0.00001). In conclusion, this meta-analysis suggested that PLR was significantly associated with the OS of HCC.

Keywords

Hepatocellular carcinoma Platelet-to-lymphocyte ratio Survival.
Hu, D.-H., & Yu, S.-M. (2017). Association between platelet to lymphocyte ratio (PLR) and overall survival (OS) of hepatocellular carcinoma (HCC): A meta-analysis. Cellular and Molecular Biology, 63(8), 30–32. https://doi.org/10.14715/cmb/2017.63.8.7
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