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Vol. 64 No. 1: Issue 1

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Circulating prolactin levels and Behcet's disease: A meta-analysis

https://doi.org/10.14715/cmb/2018.64.1.4
Gwan Gyu Song
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Young Ho Lee
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

Corresponding Author(s) : Young Ho Lee

lyhcgh@korea.ac.kr

Cellular and Molecular Biology, Vol. 64 No. 1: Issue 1

Abstract

This study aimed to summarize the current evidence on the relationship between circulating prolactin levels and Behcet's disease (BD). We performed a meta-analysis comparing the serum/plasma prolactin levels in patients with BD with those of controls and performed a subgroup analysis based on ethnicity, disease activity, and sex. Ten articles with a total of 320 patients with BD and 259 controls were included. The prolactin levels were not significantly higher in the BD group than in the control group (SMD=0.208, 95% CI=-0.012–0.428, p=0.064). Stratification by ethnicity indicated no elevation in prolactin level in Turkish patients with BD (SMD=0.127, 95% CI=-0.111–0.366, p=0.295). Stratification by disease activity revealed no elevation in prolactin level in both the active and inactive BD groups compared with the control group (SMD=0.373, 95% CI=-0.095–0.841, p=0.119; SMD=0.055, 95% CI=-0.243–0.354, p=0.717). Stratification by sex revealed no elevation in prolactin level in both the female and male BD groups (SMD=0.031, 95% CI=-0.398–0.460, p=0.888; SMD=0.279, 95% CI=-1.411–1.969, p=0.746). The prolactin levels were not significantly elevated in patients with BD, regardless of the adjustments for age/sex, sample size, or data type evaluated. This meta-analysis of current evidence suggests that circulating prolactin levels may not be higher in patients with BD than in controls.

Keywords

Prolactin level Behcet's disease.
Song, G. G., & Lee, Y. H. (2018). Circulating prolactin levels and Behcet’s disease: A meta-analysis. Cellular and Molecular Biology, 64(1), 14–18. https://doi.org/10.14715/cmb/2018.64.1.4
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