Association between BANK1 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis

S-C. Bae; Y. H. Lee

doi:10.14715/cmb/2017.63.3.6

Issue

Vol. 63 No. 3: Issue 3

Issue Published : May 3, 2017

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Association between BANK1 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis

https://doi.org/10.14715/cmb/2017.63.3.6

S-C. Bae

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Division of Rheumatology, Korea University College of Medicine, Seoul, Korea

Y. H. Lee

Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

Corresponding Author(s) : Y. H. Lee

lyhcgh@korea.ac.kr

Cellular and Molecular Biology, Vol. 63 No. 3: Issue 3
Article Published : March 31, 2017

Abstract

This study aimed to explore whether BANK1 polymorphisms are associated with susceptibility to autoimmune diseases. We conducted a meta-analysis on the associations between the BANK1 rs10516487, rs3733197, and rs17266594 polymorphisms and autoimmune diseases. Twenty-two articles with a total of 22,684 patients and 36,437 controls were included in the meta-analysis. Meta-analysis revealed a significant association between autoimmune diseases and the BANK1 rs10516487 T allele (OR = 1.161, 95% CI = 1.092–1.275, p = 1.9 í— 10-6, heterogeneity p < 0.001). The analysis also revealed an association between autoimmune diseases and the BANK1 rs3733197 A allele (OR = 1.178, 95% CI = 1.105–1.256, p = 4.5 í— 10-7, heterogeneity p = 0.002) and the rs17266594 T allele (OR = 1.189, 95% CI = 1.073–1.315, p = 0.001, heterogeneity p < 0.001). Meta-analysis by autoimmune disease type revealed an association between both systemic lupus erythematosus and systemic sclerosis and the BANK1 rs10516487 T allele (OR = 1.294, 95% CI = 1.232–1.360, p < 1.0 í— 10-8, heterogeneity p = 0.556; OR = 1.102, 95% CI = 1.027–1.183, p = 0.017, heterogeneity p = 0.048). However, meta-analysis failed to indicate an association between the BANK1 rs10516487 T allele and rheumatoid arthritis (RA; OR = 1.006, 95% CI = 1.956–1.058, p = 0.819). This meta-analysis demonstrates that BANK1 rs10516487, rs3733197, and rs17266594 polymorphisms are associated with susceptibility to autoimmune diseases.

Keywords

Autoimmune diseases BANK1 Polymorphism Meta-analysis.

Bae, S.-C., & Lee, Y. H. (2017). Association between BANK1 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis. Cellular and Molecular Biology, 63(3), 29–35. https://doi.org/10.14715/cmb/2017.63.3.6