ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians: an update meta-analysis

K-L. Li; C-Y. Chen; M. Xu; X-Q. Zhu; X-J. Yang

doi:10.14715/cmb/2017.63.10.22

Issue

Vol. 63 No. 10: Issue 10

Issue Published : November 1, 2017

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ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians: an update meta-analysis

https://doi.org/10.14715/cmb/2017.63.10.22

K-L. Li

Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China

C-Y. Chen

Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China

M. Xu

Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China

X-Q. Zhu

Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China

X-J. Yang

Department of Internal Medicine, Shanghai Electric Power Hospital, Shanghai 200050, China

Corresponding Author(s) : M. Xu

xumin76@yeah.net

Cellular and Molecular Biology, Vol. 63 No. 10: Issue 10
Article Published : October 31, 2017

Abstract

Some reports evaluated the association between ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians. The results remained unknown. Thus, we did a meta-analysis to evaluate this association. Nine case-control studies with 4198 patients and 3699 controls were included in this meta-analysis. A significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in Caucasians (OR=1.18; 95%CI, 1.08–1.28; P=0.0002). ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians from Europe (OR=1.20; 95%CI, 1.09–1.32; P=0.0002) but not from other countries (OR=1.13; 95%CI, 0.95–1.36; P=0.17). No significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in males (OR=1.12; 95%CI, 0.91–1.39; P=0.28). Moreover, ALOX5AP rs10507391 polymorphism was not associated with cardioembolic ischemic stroke risk (OR=1.04; 95%CI, 0.73–1.48; P=0.84). In conclusion, this study found that ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians.

Keywords

ALOX5AP Ischemic stroke Genetic Polymorphism.

Li, K.-L., Chen, C.-Y., Xu, M., Zhu, X.-Q., & Yang, X.-J. (2017). ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians: an update meta-analysis. Cellular and Molecular Biology, 63(10), 137–140. https://doi.org/10.14715/cmb/2017.63.10.22