Issue

Vol. 65 No. 1: Issue 1

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Different VDR, VDBP genotypes and vitamin D levels may effect obstructive sleep apnea syndrome

https://doi.org/10.14715/cmb/2019.65.1.8
Deniz Kirac
Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey
Ozge Yagcioglu Yassa
Department of Neurology, Erenkoy Mental and Nervous Diseases Training and Reserach Hospital, Istanbul, Turkey
Hazal Gezmis
Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey
Saime Fusun Mayda Domac
Department of Neurology, Erenkoy Mental and Nervous Diseases Training and Reserach Hospital, Istanbul, Turkey
Elif Cigdem Altunok
Department of Biostatistics, Faculty of Medicine, Yeditepe University, Istanbul, Turkey
Ece Genc
Department of Medical Pharmacology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey

Corresponding Author(s) : Deniz Kirac

denizyat@hotmail.com

Cellular and Molecular Biology, Vol. 65 No. 1: Issue 1

Abstract

Obstructive sleep apnea syndrome (OSAS) is a highly prevalent disorder which results in markedly reduced (hypopnea) or absent (apnea) airflow at the nose/mouth. Since vitamin D deficiency has found in an association with some disorders it is thought to be related with OSAS progression. The aim of this study is to investigate the association between VDR, VDBP mutations, vitamin D level and some environmental risk factors with OSAS. Fifty individuals who were diagnosed as OSAS were selected as patients, 50 healthy volunteers without any disease were selected as controls. FokI (rs2228570) and BsmI (rs1544410) mutations in VDR; rs4588 and rs7041 mutations in VDBP were investigated with quantitative real-time polymerase chain reaction (qPCR). Other risk factors were also investigated. Results were evaluated statistically. Statistically significant differences were observed according to the baseline characteristics between the groups, When groups were compared with each other, CA genotype in rs4588, CC genotype in rs2228570 and AA genotype in rs1544410 mutations were found statistically significant in patients whereas TC genotype in rs2228570 and GA genotype in rs1544410 mutations were found statistically significant in controls. When the relation between risk factors and genotypes were investigated, statistically significant associations were detected for body mass index (BMI), waist circumference, Apnea–Hypopnea Index (AHI), excessive daytime sleepiness (EDS), vitamin D and triglyceride levels. VDR and VDBP mutations were found highly related with OSAS. Possible tracking of these mutations and risk factors may help to understand the metabolism as well as the progression of the disease.

Keywords

OSAS VDR VDBP Vitamin D qPCR.
Kirac, D., Yagcioglu Yassa, O., Gezmis, H., Mayda Domac, S. F., Altunok, E. C., & Genc, E. (2019). Different VDR, VDBP genotypes and vitamin D levels may effect obstructive sleep apnea syndrome. Cellular and Molecular Biology, 65(1), 46–51. https://doi.org/10.14715/cmb/2019.65.1.8
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Barcelo A, Esquinas C, Pierola J, De la Pena M, Sanchez-de-la-Torre M, Montserrat JM et al. Vitamin D status and parathyroid hormone levels in patients with obstructive sleep apnea. Respiration 2013; 86(4):295-30. doi: 10.1159/000342748
  2. McNicholas WT, Bonsigore MR. Management Committee of ECAB. Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J 2007; 29(1):156-78. doi: 10.1183/09031936.00027406
  3. McNicholas WT. Diagnosis of obstructive sleep apnea in adults. Proc Am Thorac Soc 2008; 5(2):154-60. doi: 10.1513/pats.200708-118MG
  4. Xu H, Guan J, Yi H, Zou J, Meng L, Tang X et al. Elevated low-density lipoprotein cholesterol is independently associated with obstructive sleep apnea: evidence from a large-scale cross-sectional study. Sleep Breath 2016; 20(2):627-34. doi: 10.1007/s11325-015-1262-3
  5. McCarty DE, Chesson AL, Jr., Jain SK, Marino AA. The link between vitamin D metabolism and sleep medicine. Sleep Med Rev 2014; 18(4):311-9. doi: 10.1016/j.smrv.2013.07.001
  6. Kerley CP, Hutchinson K, Bolger K, McGowan A, Faul J, Cormican L. Serum Vitamin D Is Significantly Inversely Associated with Disease Severity in Caucasian Adults with Obstructive Sleep Apnea Syndrome. Sleep 2016; 39(2):293-300. doi: 10.5665/sleep.5430
  7. McCarty DE, Reddy A, Keigley Q, Kim PY, Marino AA. Vitamin D, race, and excessive daytime sleepiness. J Clin Sleep Med 2012; 8(6):693-7. doi: 10.5664/jcsm.2266
  8. Young KA, Snell-Bergeon JK, Naik RG, Hokanson JE, Tarullo D, Gottlieb PA et al. Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes. Diabetes Care 2011; 34(2):454-8. doi: 10.2337/dc10-0757
  9. Abu El Maaty MA, Hassanein SI, Gad MZ. Genetic variation in vitamin D receptor gene (Fok1:rs2228570) is associated with risk of coronary artery disease. Biomarkers 2016; 21(1):68-72. doi: 10.3109/1354750X.2015.1118535
  10. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004; 338(2):143-56. doi: 10.1016/j.gene.2004.05.014
  11. Laczmanski L, Milewicz A, Lwow F, Puzianowska-Kuznicka M, Pawlak M, Kolackov K et al. Vitamin D receptor gene polymorphism and cardiovascular risk variables in elderly Polish subjects. Gynecol Endocrinol 2013; 29(3):268-72. doi: 10.3109/09513590.2012.736562
  12. Yao P, Sun L, Lu L, Ding H, Chen X, Tang L et al. Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25ï›OHï”D Responses to Vitamin D Supplementation. J Clin Endocrinol Metab 2017; 102(1):100-10. doi: 10.1210/jc.2016-2930
  13. Verschuren JJ, Trompet S, Sampietro ML, Heijmans BT, Koch W, Kastrati A et al. Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene. PLoS One 2013; 8(8):e70676. doi: 10.1371/journal.pone.0070676
  14. Pilz S, Tomaschitz A, Ritz E, Pieber TR. Vitamin D status and arterial hypertension: a systematic review. Nat Rev Cardiol 2009; 6(10):621-30. doi: 10.1038/nrcardio.2009.135
  15. Pellegrino R, Mazzotti DR, Guindalini C, Santos-Silva R, Bittencourt LR, Tufik S. Apolipoprotein E polymorphisms and sleep quality in obstructive sleep apnea syndrome. Clin Chim Acta 2011; 412(23-24):2223-7. doi: 10.1016/j.cca.2011.08.007
  16. Basoglu OK, Tasbakan MS. Gender differences in clinical and polysomnographic features of obstructive sleep apnea: a clinical study of 2827 patients. Sleep Breath 2017; doi: 10.1007/s11325-017-1482-9
  17. Valipour A. Gender-related differences in the obstructive sleep apnea syndrome. Pneumologie 2012; 66(10):584-8. doi: 10.1055/s-0032-1325664
  18. Kheirandish-Gozal L, Peris E, Gozal D. Vitamin D levels and obstructive sleep apnoea in children. Sleep Med 2014; 15(4):459-63. doi: 10.1016/j.sleep.2013.12.009
  19. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002; 288(14):1723-7.
  20. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993; 328(17):1230-5. doi: 10.1056/NEJM199304293281704
  21. Kyzer S, Charuzi I. Obstructive sleep apnea in the obese. World J Surg 1998; 22(9):998-1001.
  22. Azagra-Calero E, Espinar-Escalona E, Barrera-Mora JM, Llamas-Carreras JM, Solano-Reina E. Obstructive sleep apnea syndrome (OSAS). Review of the literature. Med Oral Patol Oral Cir Bucal 2012; 17(6):e925-9.
  23. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357(3):266-81. doi: 10.1056/NEJMra070553
  24. Tauman R, O'Brien LM, Ivanenko A, Gozal D. Obesity rather than severity of sleep-disordered breathing as the major determinant of insulin resistance and altered lipidemia in snoring children. Pediatrics 2005; 116(1):e66-73. doi: 10.1542/peds.2004-2527
  25. Meslier N, Gagnadoux F, Giraud P, Person C, Ouksel H, Urban T et al. Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome. Eur Respir J 2003; 22(1):156-60.
  26. Borgel J, Sanner BM, Bittlinsky A, Keskin F, Bartels NK, Buechner N et al.Obstructive sleep apnoea and its therapy influence high-density lipoprotein cholesterol serum levels. Eur Respir J 2006; 27(1):121-7. doi: 10.1183/09031936.06.00131304
  27. Schafer H, Pauleit D, Sudhop T, Gouni-Berthold I, Ewig S, Berthold HK. Body fat distribution, serum leptin, and cardiovascular risk factors in men with obstructive sleep apnea. Chest 2002; 122(3):829-39.
  28. Pampati S, Manchikanti L. What Is the Prevalence of Symptomatic Obstructive Sleep Apnea Syndrome in Chronic Spinal Pain Patients? An Assessment of the Correlation of OSAS with Chronic Opioid Therapy, Obesity, and Smoking. Pain Physician 2016; 19(4):E569-79.
  29. Trenchea M, Deleanu O, Suta M, Arghir OC.) Smoking, snoring and obstructive sleep apnea. Pneumologia 2013; 62(1):52-5.
  30. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14(6):540-5.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 914 Download : 519

Most read articles by the same author(s)