Issue

Vol. 64 No. 15: Issue 15

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Combined detection of CEA and CA125 for the diagnosis for lung cancer: A meta-analysis

https://doi.org/10.14715/cmb/2017.64.15.11
Li-xin Wu
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
Xiao-feng Li
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
Hua-fei Chen
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
You-cai Zhu
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
Wen-xian Wang
Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou Zhejiang 310022, China
Chun-wei Xu
Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou Fujian 350014, China
Dong-fang Xie
Department of Pathology, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
Yang Wan
Clinical Pathology Center, The fourth Affiliated Hospital of Anhui Medical University, Hefei Anhui 230012, China
Kai-qi Du
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China

Corresponding Author(s) : Li-xin Wu

xiaoyaoren101@hotmail.com

Cellular and Molecular Biology, Vol. 64 No. 15: Issue 15

Abstract

This study aimed to systematically evaluate the value of combined detection of serum CEA and CA125 concentrations for the diagnosis of lung cancer. Related studies regarding the diagnosis of lung cancer were searched in PubMed, Embase, CNKI, and Wanfang using a computer. The number of patients who were true-positive, false-positive, false-negative, and true-negative were extracted from each study. Meta-analysis was performed using the Meta-Disc l.4, RevMan 5.3. Seven studies involving 2,216 cases were finally included. Regarding the diagnosis of lung cancer, the sensitivity, specificity, and diagnostic odds ratio of combined CEA and CA125 detection were higher than those of CEA detection alone. The area under the curve (AUC) of combined detection was 0.90, whereas the independently detected AUC was 0.73. Combined CEA and CA125 detection has higher diagnostic efficiency for lung cancer than CEA detection alone. The significance of combined serum CEA and CA125 detection in lung cancer is confirmed.

Keywords

Diagnosis Meta-analysis Lung cancer CA125 CEA.
Wu, L.- xin, Li, X.- feng, Chen, H.- fei, Zhu, Y.- cai, Wang, W.- xian, Xu, C.- wei, Xie, D.- fang, Wan, Y., & Du, K.- qi. (2018). Combined detection of CEA and CA125 for the diagnosis for lung cancer: A meta-analysis. Cellular and Molecular Biology, 64(15), 67–70. https://doi.org/10.14715/cmb/2017.64.15.11
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Sriram KB, Larsen JE, Yang IA, Bowman RV, Fong KM. Genomic medicine in non-small cell lung cancer: Paving the path to personalized care. Respirology 2011; 16:257-263.
  2. Han KQ, Huang G, Gao CF, Wang XL, Ma B, Sun LQ, et al. Identification of lung cancer patients by serum protein profiling using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. Am J Clin Oncol 2008; 31:133-139.
  3. Gupta JK, Chien PF, Voit D, Li A. Ultrasonographic endomertrial thickness for diagnosing test into a summary ROC curve: Data-analytic approaches and some additional considerations. Health Technol Assess 2005; 9:1-113.
  4. Walter SD. Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data. Stat Med 2002; 21:1237-1256.
  5. Liu YX, Wang JZ, Liu JP, Li A. Meta analysis in the application of diagnostic test evaluation. Chinese Journal of Health Statistics 2005; 22:16-19.
  6. Moses LE, Shapiro D, Littenberg B. Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations. Stat Med 1993; 12:1293-1316.
  7. Zeng C, Quan GL, Wamg CL, Li A. Combined detection of six serum tumor markers in the diagnosis for lung cancer. Guangdong Med 2012; 33:808-810.
  8. Chen F, Li WM, Wang DM, Gao CS, Bao Y, Chen WB, et al. The value of detecting serum tumor markers together in lung cancer diagnosis. Journal of Sichuan University (medical edition) 2008; 5:832-835.
  9. Zhang HY, Li A. The application of CEA and CA125 in diagnosis of lung cancer. Medical Laboratory Science and Clinices 2013; 10:3335-3336.
  10. Ye HY, Han SS, Ye YL, Li A. The diagnostic value of CA125 and CEA on non-small cell lung cancer. Journal of Clinical Hematology (Blood transfusion and testing) 2016; 29:479-481.
  11. Cai JK, Shi WJ, Gao TM, Li A. Clinical value of serum tumor markers in non-small cell lung cancer. Jiangsu Medicine 2003; 3:191-192.
  12. Ma L, Xie XW, Wang HY, Ma LY, Wen ZG. Clinical evaluation of tumor markers for diagnosis in patients with non-small cell lung cancer in china. Asian Pac J Cancer Prev 2015; 16:4891-4894.
  13. Yao YC, Li A. The clinical application value of CA125, CYFRA21-1 and CEA in non-small cell lung cancer. Clinical and clinical trials 12:1659-1660.
  14. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11-30.
  15. Jan CR, Lu YC, T Seng LL. Effect of the antidepressant desipramine on cytosolic (Ca2+): Movement and proliferation in human ostcosarcoma cells. Pharmacology 2003; 69:190-196.
  16. GOLD P, Freedman S. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med 1965; 121:439-462.
  17. Ni J, Guo ZJ, Zhang L, Li A. The value of four lung cancer serum tumor markers in lung cancer diagnosis by single and combined detection. Chinese Journal of Internal Medicine 2016; 55:25-30.
  18. Lee S, Lee CY, Kim DJ, Li A. Pathologic correlation of serum carcinoembryonic antigen and cytokeratin 19 fragment in resected nonsmall cell lung cancer. Korean J Thorac Cardiovasc Surg 2013; 46:192-196.
  19. Vitone LJ, Greenhalf W, Howes NR. Hereditary pancreatitis and secondary screening for early pancreatic cancer. Rocz Akad Med Bialymst 2011; 50:73-84.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 948 Download : 537

Similar Articles

You may also start an advanced similarity search for this article.