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Vol. 64 No. 15: Issue 15

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Combined detection of CEA and CA125 for the diagnosis for lung cancer: A meta-analysis

https://doi.org/10.14715/cmb/2017.64.15.11
Li-xin Wu
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
Xiao-feng Li
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
Hua-fei Chen
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
You-cai Zhu
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
Wen-xian Wang
Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou Zhejiang 310022, China
Chun-wei Xu
Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou Fujian 350014, China
Dong-fang Xie
Department of Pathology, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China
Yang Wan
Clinical Pathology Center, The fourth Affiliated Hospital of Anhui Medical University, Hefei Anhui 230012, China
Kai-qi Du
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing Zhejiang 314000, China

Corresponding Author(s) : Li-xin Wu

xiaoyaoren101@hotmail.com

Cellular and Molecular Biology, Vol. 64 No. 15: Issue 15

Abstract

This study aimed to systematically evaluate the value of combined detection of serum CEA and CA125 concentrations for the diagnosis of lung cancer. Related studies regarding the diagnosis of lung cancer were searched in PubMed, Embase, CNKI, and Wanfang using a computer. The number of patients who were true-positive, false-positive, false-negative, and true-negative were extracted from each study. Meta-analysis was performed using the Meta-Disc l.4, RevMan 5.3. Seven studies involving 2,216 cases were finally included. Regarding the diagnosis of lung cancer, the sensitivity, specificity, and diagnostic odds ratio of combined CEA and CA125 detection were higher than those of CEA detection alone. The area under the curve (AUC) of combined detection was 0.90, whereas the independently detected AUC was 0.73. Combined CEA and CA125 detection has higher diagnostic efficiency for lung cancer than CEA detection alone. The significance of combined serum CEA and CA125 detection in lung cancer is confirmed.

Keywords

Diagnosis Meta-analysis Lung cancer CA125 CEA.
Wu, L.- xin, Li, X.- feng, Chen, H.- fei, Zhu, Y.- cai, Wang, W.- xian, Xu, C.- wei, Xie, D.- fang, Wan, Y., & Du, K.- qi. (2018). Combined detection of CEA and CA125 for the diagnosis for lung cancer: A meta-analysis. Cellular and Molecular Biology, 64(15), 67–70. https://doi.org/10.14715/cmb/2017.64.15.11
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