Issue
Stem cell therapy for lung diseases: From fundamental aspects to clinical applications
Corresponding Author(s) : Hamid Tebyanian
Cellular and Molecular Biology,
Vol. 64 No. 10: Issue 10
Abstract
The respiratory system is a complex group of organs in the human body, all of which are necessary in breathing. Due to its special anatomy and composition, after exposure to various damaging factors such as micro particles, carbon granules and toxic gases, the respiratory system can be affected by a variety of damage without return to its original state. Currently, the prevalence of lung diseases, including asthma, and chronic obstructive pulmonary diseases, such as emphysema, has increased remarkably. New therapeutic approaches are desperately needed to discover regenerative medicine approaches, especially cell therapy. This review summarizes the recent advances in stem cell treatments and the research efforts conducted through the application of stem cell therapy for respiratory system diseases. In particular, researchers have used animal models to gather data about treating lung injury by stem cell transplantation. This review concentrated on the findings about route, timing and adjustment of cell transplantation dose, optimum stem cell type selection and potency marker of cells as therapeutic agents. These factors are essential subjects for approval and clinical transplantation. The current clinical trials aiming at treatment of lung diseases by stem cells are mentioned and discussed.
Keywords
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- Linneberg A, Dam Petersen K, Hahn-Pedersen J, Hammerby E, Serup-Hansen N, Boxall N. Burden of allergic respiratory disease: a systematic review. Clin Mol Allergy 2016; 14.
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References
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Albertine KH, Jones GP, Starcher BC, Bohnsack JF, Davis PL, Cho S-C, et al. Chronic lung injury in preterm lambs: disordered respiratory tract development. Am J Respir Crit Care Med 1999; 159:945–958.
Johnson ER, Matthay MA. Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv 2010; 23:243–252.
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Nejad-Moghaddam A, Panahi Y, Alitappeh MA, Borna H, Shokrgozar MA, Ghanei M. Therapeutic potential of mesenchymal stem cells for the treatment of airway remodeling in pulmonary diseases. Iran J Allergy Asthma Immunol 2015; 14:552.
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Rock JR, Hogan BLM. Epithelial Progenitor Cells in Lung Development, Maintenance, Repair, and Disease. Annu Rev Cell Dev Biol 2011; 27:493–512.
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Rackley CR, Stripp BR. Building and maintaining the epithelium of the lung. J Clin Invest 2012; 122:2724–30.
Perl A-KT, Wert SE, Loudy DE, Shan Z, Blair PA, Whitsett JA. Conditional Recombination Reveals Distinct Subsets of Epithelial Cells in Trachea, Bronchi, and Alveoli. Am J Respir Cell Mol Biol 2005; 33:455–62.
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Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275:964–966.
Zhang M, Malik AB, Rehman J. Endothelial progenitor cells and vascular repair: Curr Opin Hematol 2014; 21:224–8.
Weiss DJ. Concise Review: Current Status of Stem Cells and Regenerative Medicine in Lung Biology and Diseases: Advances in Lung Regenerative Medicine. STEM CELLS 2014; 32:16–25.
Doyle MF, Tracy RP, Parikh MA, Hoffman EA, Shimbo D, Austin JH, et al. Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema. PloS One 2017; 12:e0173446.
Sabatier F, Camoin-Jau L, Anfosso F, Sampol J, Dignat-George F. Circulating endothelial cells, microparticles and progenitors: key players towards the definition of vascular competence. J Cell Mol Med 2009; 13:454–71.
Wei J, Blum S, Unger M, Jarmy G, Lamparter M, Geishauser A, et al. Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Cancer Cell 2004; 5:477–488.
Yoder MC. Human Endothelial Progenitor Cells. Cold Spring Harb Perspect Med 2012; 2:a006692–a006692.
Ahmed LA, Rizk SM, EL-Maraghy SA. Pinocembrin ex vivo preconditioning improves the therapeutic efficacy of endothelial progenitor cells in monocrotaline-induced pulmonary hypertension in rats. Biochem Pharmacol 2017; 138:193–204.
Shi Z, Chen Y, Cao J, Zeng H, Yang Y, Chen P, et al. Intratracheal transplantation of endothelial progenitor cells attenuates smoking-induced COPD in mice. Int J Chron Obstruct Pulmon Dis 2017; Volume 12:947–60.
Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Prolif 1970; 3:393–403.
Akram KM, Samad S, Spiteri M, Forsyth NR. Mesenchymal Stem Cell Therapy and Lung Diseases. In: Weyand B, Dominici M, Hass R, Jacobs R, Kasper C, editors. Mesenchymal Stem Cells - Basics Clin. Appl. II, vol. 130, Berlin, Heidelberg: Springer Berlin Heidelberg; 2012, p. 105–29.
Ortiz LA, DuTreil M, Fattman C, Pandey AC, Torres G, Go K, et al. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci 2007; 104:11002–11007.
Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, et al. Bone marrow–derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005; 33:145–152.
Wecht S, Rojas M. Mesenchymal stem cells in the treatment of chronic lung disease: Mesenchymal stem cells and lung injury. Respirology 2016; 21:1366–75.
Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, et al. Therapeutic Potential of Mesenchymal Stem Cells for Severe Acute Lung Injury. Chest 2010; 138:965–72.
Babavalian H, Latifi AM, Shokrgozar MA, Bonakdar S, Tebyanian H, Shakeri F. Cloning and expression of recombinant human platelet-derived growth factor-BB in Pichia Pink. Cell Mol Biol Noisy--Gd Fr 2016; 62:45–51.
Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. The Lancet 2008; 371:1579–1586.
Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, et al. Bone marrow–derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005; 33:145–152.
Reiter J, Drummond S, Sammour I, Huang J, Florea V, Dornas P, et al. Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia. Respir Res 2017; 18.
Huang X, Sun K, Zhao YD, Vogel SM, Song Y, Mahmud N, et al. Human CD34+ Progenitor Cells Freshly Isolated from Umbilical Cord Blood Attenuate Inflammatory Lung Injury following LPS Challenge. PLoS ONE 2014; 9:e88814.
Yang J, Jia Z. Cell-based therapy in lung regenerative medicine. Regen Med Res 2014; 2:7.
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