Issue

Vol. 64 No. 13: Issue 13

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Can Panax Ginseng protect against fertility disorders in hypothyroid female albino rats?

https://doi.org/10.14715/cmb/2018.64.13.18
Amany H Mahmoud Elgoly
National Organization for Drug Control and Research (NODCAR), Egypt
Lobna F Wahman
National Organization for Drug Control and Research (NODCAR), Egypt
Magda HM Yousef
Faculty of Medicine, Taibah university, KSA

Corresponding Author(s) : Lobna F Wahman

wahmanlobna@yahoo.com

Cellular and Molecular Biology, Vol. 64 No. 13: Issue 13

Abstract

Hypothyroidism is an endocrine disorder due to decreased thyroid hormone production. This endocrine disorder significantly affects the menstrual cycle and fertility. The aim of this present study was to assess the efficacy of Panax ginseng, one of traditional Chinese medicine, in ameliorating the gonadal hormonal dysfunction and lowering oxidative stress accompanied with hypothyroidism in adult female albino rats. After confirming regularity of the oestrus cycle in the female rats in this study, hypothyroidism was induced by using daily 5.0 mg kg-1 oral dose of Neo-mercazole. The hypothyroid rats were randomly grouped into two groups; hypothyroid group (H): did not received any treatment, group II (H+G) was treated with Panax ginseng extract for one months after hypothyroidism induction. Another two groups were included in the study, a negative control group (Euthyroid group) and a positive control group; received Panax ginseng extract only. Hypothyroidism resulted in irregularity of oestrus cycle accompanied with decrease in luteinizing hormone (LH), follicular stimulating hormone (FSH) and estradiol (E2), while prolactin (PRL), progesterone (P) and testosterone (T) hormone were significantly elevated. Hypothyroidism elevated capsae-3 and 8OH-deoxy guanosine expression and increased secretion of corticosterone and ERK1/2. This study showed that Panax ginseng improved hypothyroid-induced deterioration in trophic and gonadal hormones through free radicals' scavenger.

Keywords

Ginseng ROS Gonadal hormones Cortisol ERK1/2.
Elgoly, A. H. M., Wahman, L. F., & Yousef, M. H. (2018). Can Panax Ginseng protect against fertility disorders in hypothyroid female albino rats?. Cellular and Molecular Biology, 64(13), 97–102. https://doi.org/10.14715/cmb/2018.64.13.18
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Alkalby, J. M. A. and Alzerjawi, S. J. S. (2013) ‘effect of propylthiouracil-induced hypothyroidism on reproductive effeciency of adult male rats', 12(2).
  2. Kong, L. et al. (2015) ‘Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats.', The Journal of reproduction and development, 61(3), pp. 219–27. doi: 10.1262/jrd.2014-129.
  3. Wu, S. et al. (2013) ‘Metabolic Profiling Provides a System Understanding of Hypothyroidism in Rats and Its Application', PLoS ONE. doi: 10.1371/journal.pone.0055599.
  4. Shahrani, A. S. Al et al. (2016) ‘The epidemiology of thyroid diseases in the Arab world: A systematic review'.
  5. Hapon, M. B., Gamarra-luques, C. and Jahn, G. A. (2010) ‘Short term hypothyroidism affects ovarian function in the cycling rat', (Igf I), pp. 1–11.
  6. Rokot, N. T. et al. (2016) ‘A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders'. Hindawi Publishing Corporation, 2016. doi: 10.1155/2016/2614742.
  7. Wong, K. W. L. and A. S. (2013) ‘Ginseng and male reproductive function', Spermatogenesis, 3.
  8. Lee, Y. et al. (2017) ‘Implications of red Panax ginseng in oxidative stress associated chronic diseases', Journal of Ginseng Research. Elsevier Ltd, 41(2), pp. 113–119. doi: 10.1016/j.jgr.2016.03.003.
  9. Park, H. J. et al. (2016) ‘Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study', Chinese Journal of Integrative Medicine, pp. 490–495. doi: 10.1007/s11655-015-2139-9.
  10. Park K-S Kim J-W, Yun Y-J, Kim S-H, Lee C-H, Park J-W, Lee J-M, P. K.-I. (2014) ‘Efficacy and safety of Korean red ginseng for cold hypersensitivity in the hands and feet: A randomized, double-blind, placebo-controlled trial.', Journal of ethnopharmacology, p. 25. Available at: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=cctr&NEWS=N&AN=CN-01021996.
  11. Nm, I. and Nm, E. (2017) ‘Effect of Ginseng on the Testis of Subclinical Hypothyroidism Model in Adult Male Albino Rat', 4(2).
  12. Kim, M. S. et al. (2013) ‘Ginseng for managing menopause symptoms: A systematic review of randomized clinical trials', Journal of Ginseng Research, 37(1), pp. 30–36. doi: 10.5142/jgr.2013.37.30.
  13. Yeo, H. Bin et al. (2012) ‘Effects of Korean red ginseng on cognitive and motor function: A double-blind, randomized, placebo-controlled trial', Journal of Ginseng Research, pp. 190–197. doi: 10.5142/jgr.2012.36.2.190.
  14. Han, X. D. Z. Y. (2000) ‘Effect of ginseng injection on congestive heart failure and thyroid hormones', Chinese Journal of Integrated Traditional and Western Medicine. doi: 10.1007/BF02973143.
  15. Caligioni, C. (2010) ‘NIH Public Access', Curr Protoc Neurosci, pp. 1–11. doi: 10.1002/0471142301.nsa04is48.Assessing.
  16. Paz-Filho G, Hans Graf, L. S. W. (2013) ‘Comparative analysis of the new guidelines and consensuses for the management of hypothyroidism, thyroid nodules, and differentiated thyroid cancer', Arquivos Brasileiros de Endocrinologia & Metabologia, pp. 233–239. doi: 10.1590/S0004-27302013000400001.
  17. Park, S.-J. et al. (2013) ‘Subacute oral toxicity study of korean red ginseng extract in sprague-dawley rats.', Toxicological research, pp. 285–92. doi: 10.5487/TR.2013.29.4.285.
  18. Hatsuta, M. et al. (2004) ‘Effects of hypothyroidism on the estrous cycle and reproductive hormones in mature female rat', European Journal of Pharmacology, pp. 343–348. doi: 10.1016/j.ejphar.2003.12.035.
  19. Wen, L. et al. (2017) ‘Cyanidin-3-O-glucoside promotes the biosynthesis of progesterone through the protection of mitochondrial function in Pb-exposed rat leydig cells', Food and Chemical Toxicology. doi: 10.1016/j.fct.2017.10.008.
  20. Jeyaraj, D. A. et al. (2001) ‘Progesterone induced modulations of serum hormonal profiles in adult male and female rats', Endocrine Research, pp. 223–232. doi: 10.1081/ERC-100107183.
  21. Kuete, V. (2013) ‘Medicinal plant research in Africa : pharmacology and chemistry', p. 890.
  22. Murphy, L. L. and Lee, T. J.-F. (2002) ‘Ginseng, sex behavior, and nitric oxide.', Annals of the New York Academy of Sciences, pp. 372–7. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12076988.
  23. H.S., C. et al. (2015) ‘The Effect of Korean Red Ginseng on Sexual Function in Premenopausal Women: Placebo-Controlled, Double-Blind, Crossover Clinical Trial', Evidence-based Complementary and Alternative Medicine. doi: 10.1155/2015/913158.
  24. Jie, D. et al. (2015) ‘Estrogenic effect of the extract of Renshen (Radix Ginseng) on reproductive tissues in immature mice', Journal of Traditional Chinese Medicine, pp. 460–467. doi: 10.1016/S0254-6272(15)30125-4.
  25. Oh, K. J. et al. (2010) ‘Effects of korean red ginseng on sexual arousal in menopausal women: Placebo-controlled, double-blind crossover clinical study', Journal of Sexual Medicine, pp. 1469–1477. doi: 10.1111/j.1743-6109.2009.01700.x.
  26. Abdalhafid, T. Y. O. and Y. K. A. (2016) ‘effect of panax ginseng root powder on fertility and antioxidant enzymes in male rabbits', 3(5), pp. 76–83.
  27. Kim, Y. et al. (2010) ‘Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells.', Nutrition research and practice, 4(4), pp. 270–5. doi: 10.4162/nrp.2010.4.4.270.
  28. Sun, Q. et al. (2016) ‘Effects of forced swimming stress on thyroid function, pituitary thyroid-stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats', Experimental and Therapeutic Medicine, pp. 3167–3174. doi: 10.3892/etm.2016.3790.
  29. Xin, W. et al. (2017) ‘Thyroid-stimulating hormone stimulation downregulates autophagy and promotes apoptosis in chondrocytes', Endocrine Journal, pp. 749–757. doi: 10.1507/endocrj.EJ16-0534.
  30. Park, J. et al. (2017) ‘Effects of ginseng on two main sex steroid hormone receptors: estrogen and androgen receptors', Journal of Ginseng Research. Elsevier Ltd, 41(2), pp. 215–221. doi: 10.1016/j.jgr.2016.08.005.
  31. Augustin, J. M. et al. (2011) ‘Molecular activities, biosynthesis and evolution of triterpenoid saponins', Phytochemistry, pp. 435–457. doi: 10.1016/j.phytochem.2011.01.015.
  32. Yan, L. et al. (2016) ‘A Chinese herbal decoction, reformulated from Kai-Xin-San, relieves the depression-like symptoms in stressed rats and induces neurogenesis in cultured neurons', Scientific Reports. Nature Publishing Group, 6(June), pp. 1–14. doi: 10.1038/srep30014.
Read More
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 909 Download : 443