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Vol. 65 No. 1: Issue 1

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Astaxanthin suppresses cigarette smoke and lipopolysaccharide-induced airway inflammation through induction of heme oxygenase-1

https://doi.org/10.14715/cmb/2019.65.1.17
Liu Nian
Department of Respiration, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China
Zhang Weidong
Department of Respiration, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China
Luo Shujuan
Department 1 of Respiration, Hunan Children's Hospital, Changsha, Hunan 410007, China
Cao Jun
Department of Respiration, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China
Peng Minlian
Department of Respiration, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China
Liu Zhiguang
Department of Respiration, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China

Corresponding Author(s) : Liu Zhiguang

fg1308@163.com

Cellular and Molecular Biology, Vol. 65 No. 1: Issue 1

Abstract

The present study was carried out to evolve an effective treatment strategy for chronic obstructive pulmonary disease (COPD). Astaxanthin (AS) is abundantly present in red pigments of crustaceans, and has also been proven to have considerable biological activities. The anti-inflammatory effect of AS was evaluated in lipopolysaccharide (LPS)-exposed RAW264.7 macrophages. It was found that AS markedly inhibited elevation of NO and pro-inflammatory mediators. Moreover, it downregulated iNOS in LPS-stimulated RAW264.7 cells, suppressed the release of pro-inflammatory cytokines, and decreased ROS levels in mice exposed to cigarette smoke (CS) and LPS. These results imply that AS has therapeutic and prophylactic potential in the airway inflammatory response associated with COPD.

Keywords

Astaxanthin Cigarette Lipopolysaccharide-induced Heme oxygenase-1.
Nian, L., Weidong, Z., Shujuan, L., Jun, C., Minlian, P., & Zhiguang, L. (2019). Astaxanthin suppresses cigarette smoke and lipopolysaccharide-induced airway inflammation through induction of heme oxygenase-1. Cellular and Molecular Biology, 65(1), 94–99. https://doi.org/10.14715/cmb/2019.65.1.17
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