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Vol. 64 No. 15: Issue 15

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Interplay of long non-coding RNAs and TGF/SMAD signaling in different cancers

https://doi.org/10.14715/cmb/2017.64.15.1
Ammad Ahmad Farooqi
Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore
Rukset Attar
Department of Obstetrics and Gynecology, Yeditepe University, Turkey
Muhammad Zahid Qureshi
Department of Chemistry, GCU Lahore, Pakistan
Sundas Fayyaz
Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, Pakistan
Muhammad Imran Sohail
Department of Zoology, GCU Lahore, Pakistan
Uteuliyev Yerzhan Sabitaliyevich
Kazakhstan Medical University "KSPH", Kazakhstan
Sadykov Bolat Nurmurzayevich
City Clinical Hospital No.5 in Almaty, Kazakhstan
Armida Yelekenova
Department of Obstetrics and Gynecology, Astana Medical University, Kazakhstan
Ilhan Yaylim
Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
Nada Alaaeddine
Laboratoire d'immunologie cellulaire et moleculaire, Centre hospitalier de l'universite de Montreal, Tour Viger, 900 rue Saint-Denis, Montreal, Montreal H2X0A9, Quebec, Canada

Corresponding Author(s) : Ammad Ahmad Farooqi

ammadfarooqi@rlmclahore.com

Cellular and Molecular Biology, Vol. 64 No. 15: Issue 15

Abstract

Based on the exciting insights gleaned from decades of ground-breaking research, it has become evident that deregulated signaling pathways play instrumental role in cancer development and progression. Interestingly discovery of non-coding RNAs has revolutionized our understanding related to transcription, post-transcription and translation. Modern era has witnessed landmark discoveries in the field of molecular cancer and non-coding RNA biology has undergone tremendous broadening. There has been an exponential growth in the list of publications related to non-coding RNAs and overwhelmingly increasing classes of non-coding RNAs are adding new layers of complexity to already complicated nature of cancer. Regulation of TGF/SMAD signaling by miRNAs and LncRNAs has opened new horizons for therapeutic targeting of TGF/SMAD pathway. In this review we have set spotlight on central role of LncRNAs in modulation of TGF/SMAD pathway. Major proportion of the available evidence is underlining positive role of LncRNAs in contextual regulation of TGF/SMAD pathway. LncRNAs are vital to these regulatory networks because they provide a background support to make the TGF/SMAD mediated intracellular signaling more smooth or make transduction cascade more flexible in response to cues from extracellular environment. Therefore, in accordance with this notion, MALAT1, OIP5-AS1, MIR100HG, HOTAIR, ANRIL, PVT1, AFAP1-AS1, SPRY4-IT, ZEB2NAT, TUG1 and Lnc-SNHG1 have been reported to positively regulate TGF/SMAD signaling. In this review, we have focused on the regulation of TGF/SMAD signaling by LncRNAs and how these non-coding RNAs can be therapeutically exploited. Short-interfering RNA (siRNA) and natural products are currently being tested for efficacy against different LncRNAs. Nanotechnological strategies to efficiently deliver LncRNA-targeting siRNAs are also currently being investigated in different cancers.

Keywords

Cancer TGF SMAD Signaling LncRNA MALAT1 HOTAIR ANRIL.
Farooqi, A. A., Attar, R., Qureshi, M. Z., Fayyaz, S., Sohail, M. I., Sabitaliyevich, U. Y., Nurmurzayevich, S. B., Yelekenova, A., Yaylim, I., & Alaaeddine, N. (2018). Interplay of long non-coding RNAs and TGF/SMAD signaling in different cancers. Cellular and Molecular Biology, 64(15), 1–6. https://doi.org/10.14715/cmb/2017.64.15.1
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