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Vol. 65 No. 5: Issue 5

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Protective effect of sakuranetin in brain cells of dementia model rats

https://doi.org/10.14715/cmb/2019.65.5.9
Chen Li
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Chunting Hu
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Ruili Wang
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Hui Wang
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Qiaoya Ma
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Songsheng Chen
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Ya He
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China

Corresponding Author(s) : Chen Li

nfhdw8@163.com

Cellular and Molecular Biology, Vol. 65 No. 5: Issue 5

Abstract

Alzheimer's disease (AD) is a high-incidence neurodegenerative disease with complex and diverse pathogenesis. With aging of the population and continuous improvement of living standards, the incidence of AD is on the increase. Therefore, there is need to develop more effective AD drugs in order to improve the quality of life of the elderly. Sakuranetin (SAK) is a dihydroflavonoid compound extracted from plants. It has many physiological properties. In this study, the effect of SAK on spatial discrimination in a rat model of cognitive dysfunction exposed to D-galactose was investigated with respect to its effect on malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels, and on the expressions of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and nuclear factor-κB inhibitory factor-α (IκBα) in hippocampus of rats. The results obtained suggest that SAK may exert protective effects on brain cells through anti-oxidation mechanism. Moreover, the improvement in learning and memory impairment by SAK may also be related to the inhibition of inflammatory mediators in brain tissue. These findings provide scientific evidence that can be exploited for more effective treatment of Alzheimer's disease.

Keywords

Sakuranetin Dementia model Brain cells D-galactose.
Li, C., Hu, C., Wang, R., Wang, H., Ma, Q., Chen, S., & He, Y. (2019). Protective effect of sakuranetin in brain cells of dementia model rats. Cellular and Molecular Biology, 65(5), 54–58. https://doi.org/10.14715/cmb/2019.65.5.9
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