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Vol. 65 No. 5: Issue 5

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Protective effect of sakuranetin in brain cells of dementia model rats

https://doi.org/10.14715/cmb/2019.65.5.9
Chen Li
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Chunting Hu
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Ruili Wang
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Hui Wang
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Qiaoya Ma
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Songsheng Chen
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China
Ya He
Department of Geriatrics Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi, China

Corresponding Author(s) : Chen Li

nfhdw8@163.com

Cellular and Molecular Biology, Vol. 65 No. 5: Issue 5

Abstract

Alzheimer's disease (AD) is a high-incidence neurodegenerative disease with complex and diverse pathogenesis. With aging of the population and continuous improvement of living standards, the incidence of AD is on the increase. Therefore, there is need to develop more effective AD drugs in order to improve the quality of life of the elderly. Sakuranetin (SAK) is a dihydroflavonoid compound extracted from plants. It has many physiological properties. In this study, the effect of SAK on spatial discrimination in a rat model of cognitive dysfunction exposed to D-galactose was investigated with respect to its effect on malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels, and on the expressions of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and nuclear factor-κB inhibitory factor-α (IκBα) in hippocampus of rats. The results obtained suggest that SAK may exert protective effects on brain cells through anti-oxidation mechanism. Moreover, the improvement in learning and memory impairment by SAK may also be related to the inhibition of inflammatory mediators in brain tissue. These findings provide scientific evidence that can be exploited for more effective treatment of Alzheimer's disease.

Keywords

Sakuranetin Dementia model Brain cells D-galactose.
Li, C., Hu, C., Wang, R., Wang, H., Ma, Q., Chen, S., & He, Y. (2019). Protective effect of sakuranetin in brain cells of dementia model rats. Cellular and Molecular Biology, 65(5), 54–58. https://doi.org/10.14715/cmb/2019.65.5.9
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References
  1. Hu X, Wang T, Jin F. Alzheimer's disease and gut microbiota. Sci Sin (Vitae) 2016; 59: 1006-1023.
  2. Reitz C, Mayeux R. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol 2014; 88: 640-651.
  3. Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med 2016; 8: 595-608.
  4. del Ser T, Steinwachs KC, Gertz HJ, Andres MV, Gomez-Carrillo B, Medina M, et al. Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study. J Alzheimers Dis 2013; 33: 205-215.
  5. Swerdlow RH, Burns JM, Khan SM. The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives. Biochim Biophys Acta 2014; 1842: 1219-1231.
  6. Zhang L, Fang Y, Xu Y, Lian Y, Xie N, Wu T, et al. Curcumin improves amyloid β-peptide (1-42) induced spatial memory deficits through BDNF-ERK signaling pathway. PLoS One 2015; 10: 0131525.
  7. Zhan PY, Peng CX, Zhang LH. Behavior: Berberine rescues D-galactose-induced synaptic/memory impairment by regulating the levels of Arc. Pharmacol Biochem Behav 2014; 117: 47-51.
  8. Kodama O, Miyakawa J, Akatsuka T, Kiyosawa S. Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves. Phytochem 1992; 31: 3807-3809.
  9. Wollenweber E, Egger K. Flavonoid-Aglykone im Knospen-Exkret von Betula ermani. Z Pflanzenphysiol 1971; 12: 1.
  10. Mata R, Contreras JL, Crisanto D, Pereda-Miranda R, Castañeda P, Del Rio F. Chemical studies on Mexican plants used in traditional medicine, XVIII. New secondary metabolites from Dodonaea viscosa. J Nat Prod 1991; 54: 913-917.
  11. Sakoda CPP, de Toledo AC, Perini A, Pinheiro NM, Hiyane MI, dos Santos Grecco S, et al. Sakuranetin reverses vascular peribronchial and lung parenchyma remodeling in a murine model of chronic allergic pulmonary inflammation. Acta Histochem 2016; 118: 615-624.
  12. Rojas A, Cruz S, Ponce-Monter H, Mata R. Smooth muscle relaxing compounds from Dodonaea viscosa5. Planta Med 1996; 62: 154-159.
  13. Molnár J, Engi H, Hohmann J, Molnár P, Deli J, Wesolowska O, et al. Reversal of multidrug resistance by natural substances from plants. Curr Top Med Chem 2010; 10: 1757-1768.
  14. Toledo A, Sakoda C, Perini A, Pinheiro N, Magalhaes R, Grecco S, et al. Flavonone treatment reverses airway inflammation and remodelling in an asthma murine model. Br J Pharmacol 2013; 168: 1736-1749.
  15. Bae ON, Serfozo K, Baek SH, Lee KY, Dorrance A, Rumbeiha W, et al. Safety and efficacy evaluation of carnosine, an endogenous neuroprotective agent for ischemic stroke. Stroke 2013; 44: 205-212.
  16. Andrieu S, Coley N, Lovestone S, Aisen PS, Vellas B. Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions. Lancet Neurol 2015; 14: 926-944.
  17. Fischer R, Maier O. Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxid Med Cell Longev 2015; 2015: 610813.
  18. You SP, Zhao J, Ma L, Tudimat M, Zhang SL, Liu T. Preventive effects of phenylethanol glycosides from Cistanche tubulosa on bovine serum albumin-induced hepatic fibrosis in rats. Daru 2015; 23: 52.
  19. Murrow JR, Sher S, Ali S, Uphoff I, Patel R, Porkert M, et al. The differential effect of statins on oxidative stress and endothelial function: atorvastatin versus pravastatin. J Clin Lipidol 2012; 6: 42-49.
  20. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, et al. Blood-brain barrier breakdown in the aging human hippocampus. Neuron 2015; 85: 296-302.
  21. Su D, Zhao Y, Wang B, Xu H, Li W, Chen J, et al. Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil. PLoS One 2011; 6: 27632.
  22. Wu J, Wang A, Min Z, Xiong Y, Yan Q, Zhang J, et al. Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo. Biochem Biophys Res Commun 2011; 408: 382-387.
  23. Roberts BR, Ryan TM, Bush AI, Masters CL, Duce J. The role of metallobiology and amyloid"β peptides in Alzheimer's disease. J Neurochem 2012; 120: 149-166.
  24. Olanow C. A radical hypothesis for neurodegeneration. Trends Neurosci 1993; 16: 439-444.
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