Issue
Effects of Floium ginkgo extract and tertram ethypyrazine sodium chloride injection on expression of inflammatory cytokines and cerebral infarction
Corresponding Author(s) : Qingna Zhang
Cellular and Molecular Biology,
Vol. 66 No. 5: Issue 5
Abstract
This experiment was carried out to observe and analyze the effect of floium ginkgo extract and tertram ethypyrazine sodium chloride injection in patients with cerebral infarction. A total of 200 patients diagnosed with cerebral infarction were enrolled in the study. They were randomly divided into a research group and control group, each containing 100 patients. The control group was given routine treatment measures while the research group was given floium ginkgo extract and tertram ethypyrazine sodium chloride injection on the basis of routine treatment. The therapeutic effects of the two groups were observed and compared. After implementing different treatment schemes, the levels of MMP-9, SOD, CBV and CBF in the research group were significantly higher than those in the control group, p<0.05. The research group was lower in hs-CRP, MDA, MTT, TTP and TNF-α as compared with the control group, p<0.05. In terms of the quality of life of the two groups after six months of treatment, the scores of various indicators in the research group were all significantly superior, p<0.05. Conclusion: The treatment of cerebral infarction patients with floium ginkgo extract and tertram ethypyrazine sodium chloride injection can significantly improve the therapeutic effect, which is a relatively ideal treatment.
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- Dunne A, O'Neill LA. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci. STKE. 2003;2003(171):re3-.
- Turner MD, Nedjai B, Hurst T, Pennington DJ. Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2014 Nov 1;1843(11):2563-82.
- Berk M, Williams LJ, Jacka FN, O'Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M. So depression is an inflammatory disease, but where does the inflammation come from?. BMC Med 2013;11(1):200.
- Black PH, Garbutt LD. Stress, inflammation and cardiovascular disease. Journal of psychosomatic research. 2002 Jan 1;52(1):1-23.
- Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP. Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation. 2005; 12(5):255-69.
- Neurath MF. Cytokines in inflammatory bowel disease. Nature Reviews Immunology. 2014; 14(5):329-42.
- Dinarello CA. The IL-1 family of cytokines and receptors in rheumatic diseases. Nature Rev Rheumatol 2019; 15(10):612-32.
- Salomon BL, Leclerc M, Tosello J, Ronin E, Piaggio E, Cohen JL. Tumor necrosis factor α and regulatory T cells in oncoimmunology. Frontiers in Immunology. 2018; 9:444.
- Dinarello CA. Overview of the IL"1 family in innate inflammation and acquired immunity. Immunol Rev 2018; 281(1):8-27.
- Landén NX, Li D, Ståhle M. Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci 2016; 73(20):3861-85.
- Salaritabar A, Darvishi B, Hadjiakhoondi F, Manayi A, Sureda A, Nabavi SF, Fitzpatrick LR, Nabavi SM, Bishayee A. Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review. World J Gastroenterol 2017; 23(28):5097.
- Thiriet M. Cardiovascular Disease: An Introduction. InVasculopathies 2018 (pp. 1-90). Springer, Cham.
- Miller LM, Gal A. Cardiovascular system and lymphatic vessels. Pathologic Basis Vet Dis 2017: 561.
- Rodriguez ER, Tan CD. Cardiovascular Pathology. In Essentials of Anatomic Pathology 2016 (pp. 1295-1351). Springer, Cham.
- Bar B, Biller J. Select hyperacute complications of ischemic stroke: cerebral edema, hemorrhagic transformation, and orolingual angioedema secondary to intravenous Alteplase. Expert Rev Neurother. 2018;18(10):749-59.
- Rocha LA, Silva D, Barata"Antunes S, Cavaleiro H, Gomes ED, Silva NA, Salgado AJ. Cell and Tissue Instructive Materials for Central Nervous System Repair. Adv Funct Mater 2020; 18. doi.org/10.1002/adfm.201909083
- Huang Q, Shi B, Zhang W, Dong T, Zhao W. Applications of Reference Extract from Ginkgo Leaf Total Lactones for Quantitative Assay of Ginkgo Floium. Herald Med 2017; 36(6):665-8.
- Gafner S. Adulteration of Ginkgo biloba leaf extract. Bot Adult Bull 2018:1-8.
- Di T, Jiarui W, Shi L, Dan Z, Yingying C, Xiaomeng Z, Bing Z. Injections of ginkgo in the treatment of cerebral infarction: a systematic review and network Meta-analysis. J Trad Chin Med 2018; 38(1):1-1.
- Goonewardena SN, Pitt B, Zong H, inventors; University of Michigan, assignee. Targeted theranostics. United States Patent US 9,931,412. 2018 Apr 3.
- Kalaria R, Ferrer I, Love S. Vascular Disease, Hypoxia. Greenfield's Neuropathology-Two Volume Set. 2018 Oct 8:59.
- Nagai M, Granger DN. Inflammatory mechanisms in ischemic cerebrovascular disease. InNeuroinflammation 2018 Jan 1 (pp. 379-411). Academic Press.
- Zhao LS, Hao SX. Effect of mesalazine combined with bifidobacterium triad on oxidative stress and inflammatory response factors in patients with ulcerative colitis. Jilin Med J 2018; 39(01): 136-139.
- Srivastava S, Singh D, Patel S, Singh MR. Role of enzymatic free radical scavengers in management of oxidative stress in autoimmune disorders. Int J Biol Macromol 2017; 101:502-17.
- Hao DC, Xiao PG. Impact of Drug Metabolism/Pharmacokinetics and their Relevance Upon Traditional Medicine-based Cardiovascular Drug Research. Curr Drug Metab 2019; 20(7):556-74.
- Feng D, Lin X, Yang S, Yang Z, Xia Z, Li Z, Tang T, Fan R, Zhang C, Wang Y. Chinese Herbal Medicine Used Against Depression in China. Herb Med Depres 2016 (pp. 259-379). Springer, Cham.
- Song W, Zhao J, Yan XS, Fang X, Huo DS, Wang H, Jia JX, Yang ZJ. Mechanisms Associated with Protective Effects of Ginkgo Biloba Leaf Extraction in Rat Cerebral Ischemia Reperfusion Injury. J Toxicol Environ Health, Part A. 2019; 82(19):1045-51.
- Lebda MA, Sadek KM, Tohamy HG, Abouzed TK, Shukry M, Umezawa M, El-Sayed YS. Potential role of α-lipoic acid and Ginkgo biloba against silver nanoparticles-induced neuronal apoptosis and blood-brain barrier impairments in rats. Life Sci 2018; 212:251-60.
- Delshad E, Doosti H, Guillemin GJ, Naghedi-Baghdar H, Ayati Z, Farshchi MK, Javan R, Yousefi M. Herbal medicines for Ischemic stroke: a systematic review of controlled clinical trials. Herb Med J 2019; 1(1).
- Bordbar M, Darvishzadeh R, Pazhouhandeh M, Kahrizi D. An overview of genome editing methods based on endonucleases. Mod Genet J 2020; 15(2): 75-92.
- Chin KY, Qin C, May L, Ritchie RH, Woodman OL. New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury. Curr Drug Targets 2017; 18(15):1689-711.
- Ismail M. HDAC inhibition Protects Cardiomyocytes by Modulating Expression of Opioid Receptor and Inducing Pro-survival Autophagy by Inhibiting Class I HDACs during Cardiac Ischemia/Reperfusion (Doctoral dissertation, Verona University).
- Ghaheri M, Kahrizi D, Yari K, Babaie A, Suthar RS, Kazemi E. A comparative evaluation of four DNA extraction protocols from whole blood sample. Cell Mol Biol 2016; 62(3):120-4.
- Delshad E, Doosti H, Guillemin G, Ayati Z, Kaboli Farshchi M, Javan R, Yousefi M. Are Herbal Medicines Effective in the Treatment of Ischemic Stroke? A Systematic Review of Human-Controlled Clinical Trials. Herb Med J 2019; 4(1):44-54.
References
Dunne A, O'Neill LA. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci. STKE. 2003;2003(171):re3-.
Turner MD, Nedjai B, Hurst T, Pennington DJ. Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2014 Nov 1;1843(11):2563-82.
Berk M, Williams LJ, Jacka FN, O'Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M. So depression is an inflammatory disease, but where does the inflammation come from?. BMC Med 2013;11(1):200.
Black PH, Garbutt LD. Stress, inflammation and cardiovascular disease. Journal of psychosomatic research. 2002 Jan 1;52(1):1-23.
Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP. Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation. 2005; 12(5):255-69.
Neurath MF. Cytokines in inflammatory bowel disease. Nature Reviews Immunology. 2014; 14(5):329-42.
Dinarello CA. The IL-1 family of cytokines and receptors in rheumatic diseases. Nature Rev Rheumatol 2019; 15(10):612-32.
Salomon BL, Leclerc M, Tosello J, Ronin E, Piaggio E, Cohen JL. Tumor necrosis factor α and regulatory T cells in oncoimmunology. Frontiers in Immunology. 2018; 9:444.
Dinarello CA. Overview of the IL"1 family in innate inflammation and acquired immunity. Immunol Rev 2018; 281(1):8-27.
Landén NX, Li D, Ståhle M. Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci 2016; 73(20):3861-85.
Salaritabar A, Darvishi B, Hadjiakhoondi F, Manayi A, Sureda A, Nabavi SF, Fitzpatrick LR, Nabavi SM, Bishayee A. Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review. World J Gastroenterol 2017; 23(28):5097.
Thiriet M. Cardiovascular Disease: An Introduction. InVasculopathies 2018 (pp. 1-90). Springer, Cham.
Miller LM, Gal A. Cardiovascular system and lymphatic vessels. Pathologic Basis Vet Dis 2017: 561.
Rodriguez ER, Tan CD. Cardiovascular Pathology. In Essentials of Anatomic Pathology 2016 (pp. 1295-1351). Springer, Cham.
Bar B, Biller J. Select hyperacute complications of ischemic stroke: cerebral edema, hemorrhagic transformation, and orolingual angioedema secondary to intravenous Alteplase. Expert Rev Neurother. 2018;18(10):749-59.
Rocha LA, Silva D, Barata"Antunes S, Cavaleiro H, Gomes ED, Silva NA, Salgado AJ. Cell and Tissue Instructive Materials for Central Nervous System Repair. Adv Funct Mater 2020; 18. doi.org/10.1002/adfm.201909083
Huang Q, Shi B, Zhang W, Dong T, Zhao W. Applications of Reference Extract from Ginkgo Leaf Total Lactones for Quantitative Assay of Ginkgo Floium. Herald Med 2017; 36(6):665-8.
Gafner S. Adulteration of Ginkgo biloba leaf extract. Bot Adult Bull 2018:1-8.
Di T, Jiarui W, Shi L, Dan Z, Yingying C, Xiaomeng Z, Bing Z. Injections of ginkgo in the treatment of cerebral infarction: a systematic review and network Meta-analysis. J Trad Chin Med 2018; 38(1):1-1.
Goonewardena SN, Pitt B, Zong H, inventors; University of Michigan, assignee. Targeted theranostics. United States Patent US 9,931,412. 2018 Apr 3.
Kalaria R, Ferrer I, Love S. Vascular Disease, Hypoxia. Greenfield's Neuropathology-Two Volume Set. 2018 Oct 8:59.
Nagai M, Granger DN. Inflammatory mechanisms in ischemic cerebrovascular disease. InNeuroinflammation 2018 Jan 1 (pp. 379-411). Academic Press.
Zhao LS, Hao SX. Effect of mesalazine combined with bifidobacterium triad on oxidative stress and inflammatory response factors in patients with ulcerative colitis. Jilin Med J 2018; 39(01): 136-139.
Srivastava S, Singh D, Patel S, Singh MR. Role of enzymatic free radical scavengers in management of oxidative stress in autoimmune disorders. Int J Biol Macromol 2017; 101:502-17.
Hao DC, Xiao PG. Impact of Drug Metabolism/Pharmacokinetics and their Relevance Upon Traditional Medicine-based Cardiovascular Drug Research. Curr Drug Metab 2019; 20(7):556-74.
Feng D, Lin X, Yang S, Yang Z, Xia Z, Li Z, Tang T, Fan R, Zhang C, Wang Y. Chinese Herbal Medicine Used Against Depression in China. Herb Med Depres 2016 (pp. 259-379). Springer, Cham.
Song W, Zhao J, Yan XS, Fang X, Huo DS, Wang H, Jia JX, Yang ZJ. Mechanisms Associated with Protective Effects of Ginkgo Biloba Leaf Extraction in Rat Cerebral Ischemia Reperfusion Injury. J Toxicol Environ Health, Part A. 2019; 82(19):1045-51.
Lebda MA, Sadek KM, Tohamy HG, Abouzed TK, Shukry M, Umezawa M, El-Sayed YS. Potential role of α-lipoic acid and Ginkgo biloba against silver nanoparticles-induced neuronal apoptosis and blood-brain barrier impairments in rats. Life Sci 2018; 212:251-60.
Delshad E, Doosti H, Guillemin GJ, Naghedi-Baghdar H, Ayati Z, Farshchi MK, Javan R, Yousefi M. Herbal medicines for Ischemic stroke: a systematic review of controlled clinical trials. Herb Med J 2019; 1(1).
Bordbar M, Darvishzadeh R, Pazhouhandeh M, Kahrizi D. An overview of genome editing methods based on endonucleases. Mod Genet J 2020; 15(2): 75-92.
Chin KY, Qin C, May L, Ritchie RH, Woodman OL. New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury. Curr Drug Targets 2017; 18(15):1689-711.
Ismail M. HDAC inhibition Protects Cardiomyocytes by Modulating Expression of Opioid Receptor and Inducing Pro-survival Autophagy by Inhibiting Class I HDACs during Cardiac Ischemia/Reperfusion (Doctoral dissertation, Verona University).
Ghaheri M, Kahrizi D, Yari K, Babaie A, Suthar RS, Kazemi E. A comparative evaluation of four DNA extraction protocols from whole blood sample. Cell Mol Biol 2016; 62(3):120-4.
Delshad E, Doosti H, Guillemin G, Ayati Z, Kaboli Farshchi M, Javan R, Yousefi M. Are Herbal Medicines Effective in the Treatment of Ischemic Stroke? A Systematic Review of Human-Controlled Clinical Trials. Herb Med J 2019; 4(1):44-54.