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Vol. 66 No. 6: Issue 6

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Tuling Wendan Decoction combined with flunarizine in the treatment of migraine patients and the effect of intervention on serum cyclooxygenase-2, endothelin-1 and nitric oxide

https://doi.org/10.14715/cmb/2020.66.6.7
Xiayang Xie
Department of traditional Chinese Medicine, Lianshui county people's Hospital, Huai'an, 223400, China
Kai Shang
Department of Rehabilitation, Xuzhou Central Hospital, XuZhou, 221000, China
Xuejing Li
Department of Rehabilitation Medicine, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, 223002, China

Corresponding Author(s) : Xuejing Li

np1187@163.com

Cellular and Molecular Biology, Vol. 66 No. 6: Issue 6

Abstract

This experiment aimed to explore the curative effect of Tuling Wendan Decoction combined with flunarizine on migraine patients and the intervention effect on serum cyclooxygenase-2 (COX-2), endothelin-1 (ET-1), nitric oxide(NO) levels. For this purpose, from January 2019 to January 2020, 96 patients with migraine in our hospital were selected as the research object. Using a simple randomization method, patients who meet the criteria were assigned 1:1, and each patient was assigned a random number, of which the number 1 to 48 were the observation group, and the number 49 to 96 were the control group. The control group was treated with flunarizine, and the observation group was treated with Tuling Wendan Decoction combined with flunarizine. Comparing the efficacy, incidence of adverse reactions, the incidence of headache, cerebral blood flow rate [basal artery (BA), vertebral artery (VA), middle cerebral artery (MCA)], vascular endothelial function (serum COX-2, ET-1, NO levels), neurological function [5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), calcitonin gene-related peptide (CGRP)] before treatment, 4 weeks and 8 weeks after treatment between the two groups. The results for efficacy showed that after 8 weeks of treatment, the total effective rate of the observation group (93.75%) was higher than that of the control group (77.08%, P<0.05). In regards to the situation of headache attack, the number of headache attacks, duration, pain degree and accompanying symptom scores of the observation group after 4 weeks and 8 weeks of treatment were lower than those of the control group (P<0.05). Results of cerebral blood flow velocity showed that the blood flow velocity of BA, VA, MCA in the observation group was lower than that in the control group after 4 and 8 weeks of treatment (P<0.05). Vascular endothelial function results indicated that the serum COX-2 and ET-1 levels of the observation group were lower than those of the control group after 4 weeks and 8 weeks of treatment, and the serum NO levels were higher than that of the control group (P<0.05). The serum BDNF and CGRP levels of the observation group were lower than those of the control group after 4 weeks and 8 weeks of treatment, and the serum 5-HT levels were higher than the control group (P<0.05). The incidence of adverse reactions between the two groups was not statistically significant (P>0.05). It was concluded that Tuling Wendan Decoction combined with flunarizine is the first treatment for migraine, with definite curative effect and can effectively improve the onset of headache, reduce the speed of cerebral blood flow, regulate vascular endothelial function and nerve function, and ensure safety.

Keywords

Tuling Wendan Decoction Flunarizine Migraine Vascular endothelial function Cerebral blood flow velocity Brain-derived neurotrophic factor
Xie, X., Shang, K., & Li, X. (2020). Tuling Wendan Decoction combined with flunarizine in the treatment of migraine patients and the effect of intervention on serum cyclooxygenase-2, endothelin-1 and nitric oxide. Cellular and Molecular Biology, 66(6), 34–40. https://doi.org/10.14715/cmb/2020.66.6.7
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References
  1. Gasparini CF, Smith RA, Griffiths LR. Genetic and biochemical changes of the serotonergic system in migraine pathobiology. J Headache Pain 2017; 18(1):20.
  2. Ren C, Liu J, Zhou J, et al. Low levels of serum serotonin and amino acids identified in migraine patients. Biochem Biophys Res Commun 2018; 496(2):267-273.
  3. Edes AE, McKie S, Szabo E, et al. Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study. BMC Neurol 2019; 19(1):237.
  4. Wu S, Guo L, Qiu F, et al. Anti-migraine effect of the herbal combination of chuanxiong rhizoma and cyperi rhizoma and UPLC-MS/MS method for the simultaneous quantification of the active constituents in rat serum and cerebral cortex. Molecules 2019; 24(12):2230.
  5. Quan YP, Wang H, Zhu YX, et al. Effect of tianning decoction on hemorrheology of migraine with different syndrome types. Chin J Exp Tradit Med Form 2018; 24(03):181-187.
  6. Hu R. Clinical study on the curative effect of flavored hemi-lateral headache decoction on migraine. Chin J Control Endemic Dis 2018; 33(01):71-72.
  7. Huang TC, Lai TH. Taiwan headache society TGSOTHS medical treatment guidelines for preventive treatment of migraine. Acta Neurol Taiwan 2017; 26(1):33-35.
  8. Luo ZQ, Yu GH. Observation on the therapeutic effect of Qufeng Tongqiao Decoction on 108 cases of migraine. Pharmacol Clin Chin Mater Med 2017; 33(03):180-182.
  9. Frederiksen SD, Bekker-Nielsen Dunbar M, Snoer AH, et al. Serotonin and neuropeptides in blood from episodic and chronic migraine and cluster headache patients in case-control and case-crossover settings: asystematic review and meta-analysis. Headache 2020; 60(6):1132-1164.
  10. Wang D. Migraine inducing factors and genetics. J Int Neurol Neurosurg 2019; 46(01):113-117.
  11. Liu ZB. Modification of banxia baizhu tianma decoction to improve77 cases of migraine caused by upward disturbance of phlegm-turbidity. Chin J Modern Drug Application 2015; 9(12):248-249.
  12. Wang LN, Tian YM, Zhang Y, et al. Difference of rs-fMRI in migraine without aura patients of gan-yang hyperactivity syndrome and upward disturbance of phlegm turbidity syndrome. Chin J Integr Tradit Western Med 2019; 39(07):816-820.
  13. Yang XP, Zhang ZS, Huang HJ, et al. The experience of Chinese medicine master Xuan Guowei in treating skin diseases with rhizoma smilacis glabrae. Glob Chin Med 2019; 12(1):137-139.
  14. Jiang W, Chen X, Hu N, et al. Effects of different combinations of Ligusticum wallichii and Angelica sinensis on 5-HT, NO and NOS in migraine rats. Progr Modern Biom 2017; 17(05):830-834.
  15. Lou QP. Research on the distribution of syndrome in migraine and the treatment of Chinese medicine based on data mining. Changchun Univ Chin Med 2018; 1-42.
  16. Sun Y, Huang ZY. Clinical analysis of peripheral vasoactive substances in migraine patients with right-to-left shunt. Stud Trace Elem Heal 2019; 36(04):9-10.
  17. Hougaard A, Younis S, Iljazi A, et al. Intravenous endothelin-1 infusion does not induce aura or headache in migraine patients with aura: intravenous endothelin-1 infusion does not induce aura or headache. Headache 2020; 60(4):724-734.
  18. Wang JW. Serum levels and correlation of visfatin and COX-2 of migraineurs. Dalian Med Univ 2015; 1-42.
  19. Villalón CM, VanDenBrink AM. The role of 5-hydroxytryptamine in the pathophysiology of migraine and its relevance to the design of novel treatments. Mini Rev Med Chem 2017; 17(11):928-938.
  20. Xu XB, Liu L, Zhao LP, et al. Research progress in the correlation between migraine pathophysiological mechanism and 5-HT_7 receptor. Chin J Pain Med 2018; 24(04):274-280.
  21. Wang JJ, Pan YH. The relationship between CGRP and migraine with anxiety and depression. J Brain Nerv Dis 2017; 25(04):252-256.
  22. Dalvand LF, Hosseini F, Dehaghi SM, Torbati ES. Inhibitory Effect of Bismuth Oxide Nanoparticles Produced by Bacillus licheniformis on Methicillin-Resistant Staphylococcus aureus Strains (MRSA). Iran J Biotechnol. 2018; 16(4): e2102.
  23. Eiamphungporn W, Yainoy S, Prachayasittikul V. Enhancement of Solubility and Specific Activity of a Cu/Zn Superoxide Dismutase by Co-expression with a Copper Chaperone in Escherichia coli. Iran J Biotechnol. 2016; 14(4): 243-249.
  24. Karimi J, Mohsenzadeh S, Niazi A, Moghadam A. Differential Expression of Mitochondrial Manganese Superoxide Dismutase (SOD) in Triticum aestivum Exposed to Silver Nitrate and Silver Nanoparticles. Iran J Biotechnol. 2017; 15(4): 284-288.
  25. Mazaheri N, Naghsh N, Karimi A, Salavati H. In vivo Toxicity Investigation of Magnesium Oxide Nanoparticles in Rat for Environmental and Biomedical Applications. Iran J Biotechnol. 2019; 17(1): e1543.
  26. Wu LY, Xu JJ, Xu P, Yong B, Feng H. Enhancement of Soluble Expression and Biochemical Characterization of Two Epoxide Hydrolases from Bacillus. Iran J Biotechnol. Apr 2019; 17(2): e2189
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