Issue

Vol. 67 No. 2: Issue 2

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Expression of FOXA1 gene regulates the proliferation and invasion of human gastric cancer cells

https://doi.org/10.14715/cmb/2021.67.2.25
Yun Dai
Department of Pathology, Liyang Branch, Jiangsu People's Hospital, Liyang, Jiangsu, 213300, China
Guangming Yang
Department of Pathology, Liyang Branch, Jiangsu People's Hospital, Liyang, Jiangsu, 213300, China
Lie Yang
Department of Pathology, Liyang Branch, Jiangsu People's Hospital, Liyang, Jiangsu, 213300, China
Li Jiang
Department of Pathology, Liyang Branch, Jiangsu People's Hospital, Liyang, Jiangsu, 213300, China
Guohua Zheng
Department of Pathology, Liyang Branch, Jiangsu People's Hospital, Liyang, Jiangsu, 213300, China
Shuyin Pan
Department of Pathology, Liyang Branch, Jiangsu People's Hospital, Liyang, Jiangsu, 213300, China
Chuming Zhu
Department of General Surgery, Liyang Branch, Jiangsu People's Hospital, Liyang, Jiangsu, 213300, China

Corresponding Author(s) : Chuming Zhu

chumingzhu6@yahoo.com

Cellular and Molecular Biology, Vol. 67 No. 2: Issue 2

Abstract

Forkhead box (FOX) transcription factors regulate the development of several human cancers. However, the role and therapeutic potential of FOXA1 in gastric cancer is still largely unexplored. The results showed a significant (P < 0.05) upregulation of FOXA1 in gastric cancer tissues and cell lines. Silencing of FOXA1 in gastric cells significantly (P < 0.05) decreased their viability through induction of apoptosis. The induction of apoptosis was associated with upregulation of Bax and downregulation of Bcl-2. Additionally, FOXA1 silencing caused activation of caspase-3 and 9 with no apparent effects on the expression of caspase-8 suggestive of intrinsic apoptosis. The transwell cell invasion revealed significant (P < 0.05) decline of cell invasion of gastric cancer cells upon FOXA1 silencing. The FOXA1 knockdown further inhibited the in vivo tumor growth suggestive of its therapeutic potential. Taken together, the findings of the present revealed that FOXA1 regulates the proliferation and development of gastric cancer and may exhibit therapeutic implications in gastric cancer treatment.

Dai, Y. ., Yang, G. ., Yang, L. ., Jiang, L. ., Zheng, G. ., Pan, S. ., & Zhu, C. . (2021). Expression of FOXA1 gene regulates the proliferation and invasion of human gastric cancer cells. Cellular and Molecular Biology, 67(2), 161–165. https://doi.org/10.14715/cmb/2021.67.2.25
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
Author biographies is not available.
Crossref
Scopus
Google Scholar
Europe PMC
Download this PDF file
PDF
Statistic
Read Counter : 1110 Download : 571