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Copyright (c) 2022 Yumin Ke, Xuanxuan Zhuang, LiuXia You
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Identification of Core Genes Shared by Endometrial Cancer and Ovarian Cancer Using an Integrated Approach
Corresponding Author(s) : LiuXia You
Cellular and Molecular Biology,
Vol. 68 No. 9: Issue 9
Abstract
Ovarian cancer (OC) is one of the most commonly diagnosed cancers among women. Moreover, Endometrial cancer (EC) is a usual genital tract cancer in females; however, the hub genes and molecular pathways shared by these two cancers have not been surveyed yet. So, this study aimed to identify the common candidate genes or biomarkers and molecular pathways in OC and EC. Differences in the expressed genes between these two microarray data sets were detected. Pathway enrichment analysis and gene ontology (GO) was also performed and protein-protein interactions (PPI) network analysis was done using Cytoscape and the most important genes were identified by the Cytohubba plugin. We found that 154 common DEGs shared by OC and EC were also detected. 10 hub proteins were identified as follows: CDC20, BUB1, CENPF, KIF11, CCNB2, FOXM1, TTK, TOP2A, DEPDC1, and NCAPG. The most important and significant miRNAs were identified to be hsa-mir-186-5p, hsa-mir-192-5p, hsa-mir-215-5p, and hsa-mir-193b-3p regulated expressions of the DEGs. This investigation demonstrated that these hub genes and their miRNA might be key genes with great effects on OC and EC. However, more studies are needed for a better understanding of the role of these hub genes and their function in these two cancers.
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