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Copyright (c) 2023 Yonghu Zhang, Ping Chen
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Expression of TIM-1 in patients with glioma and its correlation with clinicopathological features
Corresponding Author(s) : Ping Chen
Cellular and Molecular Biology,
Vol. 68 No. 11: Issue 11
Abstract
The objective of this research was to investigate the expression of TIM-1 in patients with glioma and its correlation with clinicopathological features. The clinical data of 79 patients with gliomas in our hospital from February 2016 to February 2020 were selected as the research objects of this experiment. TIM-1 detection kit, ELISA and eliysion kit were used to detect TIM-1. The expression of TIM-1 was detected by an automatic immunohistochemical analyzer. Results revealed that the expression of TIM-1 in glioma tissue was abnormal, and its level was significantly higher than that in normal tissue adjacent to the tumor. The high level of TIM-1 expression in gliomas was correlated with KPS grade and histological grade., The expression level of TIM-1 in glioma tissue can affect the survival rate of patients and become one of the independent risk factors of glioma. In conclusion, the histological grade and KPS grade of glioma are related to the high-level expression of TIM-1, which not only suggests that TIM-1 is involved in the occurrence and malignant progression of glioma but also suggests that the malignant change of glioma has a high risk
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