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Copyright (c) 2023 Wei Wang
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Correlation between Extracellular Matrix Metalloproteinase Inducer in Peripheral Blood and Serum MMPs in patients with Acute Coronary Syndrome
Corresponding Author(s) : Wei Wang
Cellular and Molecular Biology,
Vol. 68 No. 11: Issue 11
Abstract
This research aimed to investigate the expression level of Extracellular matrix metalloproteinase inducer (EMMPRIN) in peripheral blood and matrix metalloproteinases (MMPs) in the serum of patients with acute coronary syndrome, and to clarify the relationship between them, so as to analyze the pathogenesis of the coronary syndrome. For this purpose, 232 patients (patient group) with the acute coronary syndrome (ACS) diagnosed in the cardiology department of our hospital from May 2020 to March 2021 were collected, and the coronary angiography results of 76 healthy people (healthy group) were collected at the same time, and the index differences between the two groups were compared. First, compare the EMMPRIN expression level of the two groups of subjects, including EMMPRIN on the surface of platelets and monocytes. Second, analyze the difference in MMPs expression level between the two groups, and compare the difference of EMMPRIN and MMPs expression levels in different types of patients according to the disease type. Finally, correlation analysis was used to evaluate the correlation between EMMPRIN and MMPs expression levels in patients, and the ability of mutual regulation between them was analyzed. Results showed that The expression levels of EMMPRIN and MMPs in patients were significantly different from those in healthy patients (P<0.05), and the expression levels of EMMPRIN and MMPs in different types of patients were significantly different (P<0.05). The distribution of coronary plaque in different types of patients was significantly different, and the expression levels of EMMPRIN and MMPs in patients with a different coronary plaque were significantly different (P<0.05). There was a positive correlation between EMMPRIN on the platelet surface and MMPs expression in serum, and a positive correlation between EMMPRIN on the monocyte surface and MMPs expression in serum. In conclusion, the peripheral blood EMMPRIN and serum MMPs in patients with acute coronary syndrome were significantly higher than those in healthy people, and the expression of EMMPRIN in patients with the acute coronary syndrome was positively correlated with serum MMPs.
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