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Vol. 69 No. 8: Issue 8

Copyright (c) 2023 Xinyuan Yu, Xiaojun Liu, Xiujuan Mi, Zhiyun Lian, Jun Tang, Guixue Wang

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Jionoside A1 alleviates ischemic stroke ischemia/reperfusion injury by promoting Nix-mediated mitophagy

Jionoside A1 promotes Nix-mediated mitophagy
https://doi.org/10.14715/cmb/2023.69.8.37
Xinyuan Yu
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, China
Xiaojun Liu
Department of Neurology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
Xiujuan Mi
Department of Neurology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
Xiaoqiong Luo
Department of Neurology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
Zhiyun Lian
Department of Neurology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
Jun Tang
Department of Neurology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
Guixue Wang
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, China

Corresponding Author(s) : Jun Tang

jun_tang@publisher.org.cn

Cellular and Molecular Biology, Vol. 69 No. 8: Issue 8

Abstract

In ischemia-reperfusion injury in ischemic stroke, mitophagy, which can remove damaged mitochondria, reduce cytotoxic damage, and enhance neurological recovery, is crucial. Jionoside A1 is a substance found in the traditional Chinese herb Rehmannia glutinosa, which may have neuroprotective effects. The fundamental objective of this work was to find out Jionoside A1's contribution to ischemia/reperfusion injury in ischemic stroke. The oxygen-glucose deprivation/reperfusion (OGD-Rep) model and the right transient middle cerebral artery occlusion (tMCAO) model were established. Jionoside A1 was used for treatment. We utilized a tiny interfering RNA (siRNA) to lower Nix expression. The results suggest that Jionoside A1 may reduce ischemic stroke. By lowering the consequences of ischemia/reperfusion injury, Rehmannia glutinosa can be utilized to treat ischemic stroke. These discoveries provide fresh experimental information for the investigation of ischemic stroke ischemia/reperfusion injury and provide some theoretical justification for their application.

Keywords

ischemic stroke ischemia/reperfusion injury Jionoside A1 Nix mitophagy
Yu, X. ., Liu, X. ., Mi, X. ., Luo, X. ., Lian, Z. ., Tang, J., & Wang, G. . (2023). Jionoside A1 alleviates ischemic stroke ischemia/reperfusion injury by promoting Nix-mediated mitophagy: Jionoside A1 promotes Nix-mediated mitophagy. Cellular and Molecular Biology, 69(8), 237–245. https://doi.org/10.14715/cmb/2023.69.8.37
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