Regulatory role of circular RNAs in oral squamous cell carcinoma: Role of circular RNAs in the progression of OSCC

Rukset  Attar; Khalida  Noel; Mirna Azalea  Romero; Uteuliyev Yerzhan  Sabitaliyevich; Ishmuratova Margarita  Yulaevna; Muhammad Zahid  Qureshi

doi:10.14715/cmb/2023.69.8.39

Issue

Vol. 69 No. 8: Issue 8

Issue Published : September 15, 2023

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Regulatory role of circular RNAs in oral squamous cell carcinoma

Role of circular RNAs in the progression of OSCC

https://doi.org/10.14715/cmb/2023.69.8.39

Rukset Attar

Department of Obstetrics and Gynecology, Yeditepe University Hospital, 34755 Istanbul, Turkey

Khalida Noel

Human Anatomy Department, College of Medicine, Al-Mustansiriyah University, Baghdad, Iraq

Mirna Azalea Romero

Facultad de Medicina, Universidad Autónoma de Guerrero, Laboratorio de Investigación Clínica, Av. Solidaridad S/N, Colonia Hornos Insurgentes, cp 39300, Acapulco, Guerrero México

Uteuliyev Yerzhan Sabitaliyevich

Scientific Center for Innovative Technologies and Research, Kazakhstan

Ishmuratova Margarita Yulaevna

E. A. Buketov Karaganda University, Kazakhstan

Muhammad Zahid Qureshi

Deanship of Educational Services, Department of Biochemistry, Qassim University, Buraydah, Al Qassim, Buraidah 51452, Saudi Arabia

Corresponding Author(s) : Rukset Attar

ruksetattar@hotmail.com

Cellular and Molecular Biology, Vol. 69 No. 8: Issue 8
Article Published : August 31, 2023

Abstract

OSCC is a genomically complicated disease and advancements in the modern era of molecular oncology have enabled researchers to portray near-to-complete resolution of signaling landscape. Over the last two decades, overwhelming proof-of-concept has established mechanistic regulatory role of non-coding RNAs in carcinogenesis, including OSCC. Circular RNAs demonstrate a burgeoning facet of oncology research and molecular biologists are only beginning to appreciate and recognize the significance of circRNAs in the pathogenesis of OSCC. Regulatory roles of non-coding RNAs in the re-shaping of signaling pathways offer plausible strategies for prevention/inhibition of OSCC. Circular RNAs have mechanistic roles in OSCC and "sponge effects" mediated by a wider variety of circRNAs need to be rationally targeted for effective cancer prevention. Phenomenal and cutting-edge research works in different types of animal models will further refine our knowledge for selection of most promising circRNAs as pharmacologically valuable targets.

Attar, R. ., Noel, K. ., Romero, M. A. ., Sabitaliyevich, U. Y. ., Yulaevna, I. M. ., & Qureshi, M. Z. . (2023). Regulatory role of circular RNAs in oral squamous cell carcinoma: Role of circular RNAs in the progression of OSCC. Cellular and Molecular Biology, 69(8), 250–257. https://doi.org/10.14715/cmb/2023.69.8.39