Copyright (c) 2023 Xue Li, Dan Li
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Natural compounds targeting cellular redox homeostasis in malignancies
Corresponding Author(s) : Dan Li
Cellular and Molecular Biology,
Vol. 69 No. 14: Cancer molecular biology: Diagnosis and treatment
Abstract
Malignant tumors are one of the diseases that are most threatening to the health of people and their life. Moreover, it has already had a great impact on social and financial problems. With the further development of science and technology, the therapeutic approaches to malignant tumors are becoming more and more effective. At present, the common therapies for malignant tumors include surgical resections, radiotherapy, targeted therapy, and immunotherapy, which contribute to effectively suppressing tumor progression. However, these treatments showed severe side effects and complications. Over the last few decades, clinicians and researchers have found that chemical compounds extracted from natural products may be useful for treating cancer. Natural compounds like paclitaxel, doxorubicin, and camptothecin, have been successfully used to treat lung cancer as chemotherapeutic medicine. Numerous new natural compounds have been discovered that can be used to treat malignant tumors. As we know, the reactive oxygen species (ROS) closely connect to the occurrence, development, and apoptosis of tumors. The concentration of ROS in tumor cells plays an important role in the growth and development of tumors. In this review, we present a summary of some natural compounds that modulate redox homeostasis. They are promising candidates for the treatment option for cancer. Moreover, we have also explained the mechanism of the pharmacological reactions of natural compounds affiliated with ROS. It is hoped that new solutions can be provided for drug treatment of tumors.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
