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Copyright (c) 2024 Mahmoud Kanan Mohsin, Zana Qadir Omer
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The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.The effect of vitamin E incorporated into injectable platelet-rich fibrin on orthodontic tooth movement in rabbits
Corresponding Author(s) : Mahmoud Kanan Mohsin
Cellular and Molecular Biology,
Vol. 70 No. 6: Issue 6
Abstract
To evaluate the effects of injectable platelet fibrin (iPRF) and combined vitamin E-iPRF on orthodontic tooth
movement (OTM) rates in rabbits, 35 male New Zealand white rabbits were involved in this study using splitmouth
design. OTM was carried out on the mandibular first premolar using 100g nickel titanium closing coil.
Right side served as study group, isolated iPRF in one group and combined vitamin E-iPRF in other group
was injected buccally and lingually (iPRF group, Vit E-iPRF group), and left side acted as positive control
group (CG) by injecting normal saline (positive CG). The rate of OTM was measured using intra-oral scanner
on days 7,14 and 21. Histological and Micro CT scan were examined on days 0, 7, 14 and 21. The iPRF and
combined Vitamin E-iPRF demonstrated significant greater rate of OTM on days 7 and 14 in comparison to
control group, only significant differences between iPRF and combined vitamin E-iPRF were seen on day 14.
In all time intervals as compared to the CG, the number of osteoclasts was significantly higher in the isolated
iPRF and combined vitamin E-iPRF groups. Significant reduction in bone volume fraction (BV/TV) was
demonstrated in iPRF and combined vitamin E-iPRF groups in all time points, however, non-significant differences
were found in trabecular thickness (Tb.Th) and trabecullar separation (Tb.Sp). Local injection of iPRF
and combined vitamin E-iPRF showed temporary increase in the rate of OTM.
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