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Copyright (c) 2025 Saja Zubair Dhabian, Mustafa Taher Hatem
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.Curcumin-mediated synthesis of copper-doped TiO2 nanocomposite for potentially promising antioxidant, wound healing, and anti-apoptosis
Corresponding Author(s) : Mustafa Taher Hatem
Cellular and Molecular Biology,
Vol. 71 No. 12: Issue 12
Abstract
The paper provides a green, eco-friendly synthesis and analysis of a novel curcumin-based, copper-doped titanium dioxide nanocomposite (CuO/TiO2 -Curcumin NC). Curcumin was also utilized as a green reducing agent and also capping agent thereby enhancing the biocompatibility and functional surface chemistry of the nanocomposite. Stability of the nanocomposite was established using various forms of analysis. The relative biological studies showed that the synthesized CuO/TiO2 -Curcumin NC had a high antioxidant capacity compared to pure curcumin and ascorbic acid. It also exhibited a strong, dose-dependent cytotoxicity to the breast cancer cell line MDA-MB-231 that is aggressive. The nanocomposite caused remarkable tumor cell apoptosis which was mainly triggered by excess production of reactive oxygen species (ROS) that caused irreversible damage of mitochondria, and caspase-activation pathways. This nanocomposite showed a concentration-related ability to inhibit the migration and proliferation of cancer cells and thus highlighted its high anti-metastatic capacity. Besides, the copper -titanium nanocomposite (CuO/TiO2-curcumin) had promising in vitro wound -healing effects. Taken together, the present results confirm the CuO/TiO2 -curcumin nanocomposite to be a highly effective, multimodal therapeutic platform, and, therefore, holds a lot of potential in biomedical applications in the future, as an enhanced antioxidant, a powerful anticancer agent, and a scaffold to promote tissue repair and regenerative medicine.
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