Signaling lansdscape of prostate cancer

X Lin; A Aslam; R Attar; I Yaylim; M Z Qureshi; S Hasnain; M I Qadir; A A Farooqi

Issue

Vol. 62 No. 1: Issue 1

Issue Published : January 31, 2016

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Signaling lansdscape of prostate cancer

X Lin

Sichuan Medical University Department of Pharmacy Luzhou China

A Aslam

Faculty of Biological Sciences, QAU Department of Microbiology Islamabad Pakistan

R Attar

Yeditepe University Medical School Istanbul Turkey

I Yaylim

Istanbul University Department of Molecular Medicine, Institute of Experimental Medicine Istanbul Turkey

M Z Qureshi

GCU Department of Chemistry Lahore Pakistan

S Hasnain

The Superior College, Lahore Lahore Pakistan

M I Qadir

Bahauddin Zakariya University Institute of Molecular Biology and Biotechnology Multan Pakistan

A A Farooqi

RLMC Laboratory For Translational Oncology and Personalized Medicine Lahore Pakistan

Corresponding Author(s) : X Lin

Cellular and Molecular Biology, Vol. 62 No. 1: Issue 1
Article Published : January 19, 2016

Abstract

Research over the decades has gradually and sequentially shown that both intratumor heterogeneity and multifocality make prostate cancer difficult to target. Different challenges associated with generation of risk-stratification tools that correlate genomic landscape with clinical outcomes severely influence clinical efficacy of therapeutic strategies. Androgen receptor mediated signaling has gained great appreciation and rewiring of AR induced signaling cascade in absence of androgen, structural variants of AR have provided near complete resolution of genomic landscape and underlying mechanisms of prostate cancer. In this review we have attempted to provide an overview of most recent advancements in our knowledge related to different signaling cascades including TGF, SHH, Notch, JAK-STAT in prostate cancer progression and development.

Keywords

Prostate cancer molecular therapeutics signaling apoptosis.

Lin, X., Aslam, A., Attar, R., Yaylim, I., Qureshi, M. Z., Hasnain, S., Qadir, M. I., & Farooqi, A. A. (2016). Signaling lansdscape of prostate cancer. Cellular and Molecular Biology, 62(1), 45–50. Retrieved from https://mail.cellmolbiol.org/index.php/CMB/article/view/779