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Vol. 63 No. 3: Issue 3

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Long non-codingRNA (lncRNA) TUG1 and the prognosis of cancer: a meta-analysis

https://doi.org/10.14715/cmb/2017.63.3.7
X-H. Yu
Department of Anesthesiology, No. 404 Hospital of PLA, Weihai 264200, Shandong, China
W. Guo
Department of Respiratory Medicine, 323th Hospital of PLA, Xi'an 710054, Shanxi, China
J. Zhang
Department of Internal Medicine, Hospital of No. 92330 Unit of PLA, Qingdao 266000, Shandong, China
C. Ma
Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao 266071, Shandong, China
A-J. Chu
Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao 266071, Shandong, China
B-L. Wen
Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao 266071, Shandong, China
X. Zhang
Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao 266071, Shandong, China
X-Y. Yan
Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao 266071, Shandong, China
C-M. Wu
Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao 266071, Shandong, China
D-M. Wang
Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao 266071, Shandong, China
Y-L. Qu
Department of Anesthesiology, No. 401 Hospital of PLA, Qingdao 266071, Shandong, China

Corresponding Author(s) : Y-L. Qu

jiyouranqd@126.com

Cellular and Molecular Biology, Vol. 63 No. 3: Issue 3

Abstract

Some studies assessed the association between lncRNA taurine-upregulated gene 1 (TUG1) and the survival in cancer. However, the results were inconclusive.  Therefore, we performed a meta-analysis to determine this association. We used the following electronic databases to search for eligible literature: PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang. We used ORs and 95% CIs to measure the association between TUG1 and the survival of cancer. There was no significant association between TUG1 and OS of cancer (HR=1.26, 95% CI=0.97-1.64). In the subgroup analysis by cancer type, significant association could be find in osteosarcoma (HR=1.72, 95% CI=1.27-2.32) and digestive system's tumors (HR=1.66, 95% CI=1.04-2.66). In conclusion, this meta-analysis study indicated that TUG1 might associate with the OS of osteosarcoma and digestive system's tumors.

Keywords

TUG1 Cancer Association.
Yu, X.-H., Guo, W., Zhang, J., Ma, C., Chu, A.-J., Wen, B.-L., Zhang, X., Yan, X.-Y., Wu, C.-M., Wang, D.-M., & Qu, Y.-L. (2017). Long non-codingRNA (lncRNA) TUG1 and the prognosis of cancer: a meta-analysis. Cellular and Molecular Biology, 63(3), 36–39. https://doi.org/10.14715/cmb/2017.63.3.7
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