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Vol. 66 No. 6: Issue 6

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Effects of Salvia miltiorrhiza and Radix astragali on the TGF-β/Smad/Wnt pathway and the pathological process of liver fibrosis in rats

https://doi.org/10.14715/cmb/2020.66.6.9
Tingting Cao
Division of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210009, China
Yuan Lu
Division of Infectious Diseases, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210009, China
Minwei Zhu
National TCM Master Zhou Zhongying's Studio, The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, China
Jiafei Cheng
Division of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210009, China
Bai Ye
1Division of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210009, China
Nanyuan Fang
Division of Infectious Diseases, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210009, China
Yueping Cui
Division of Gastroenterology, 905 Hospital of Chinese People's Liberation Army Navy, Shanghai, 200006, China
Boyu Xue
The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, China
Moslem Lari Najafi
Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran
Elham Kazemi
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Corresponding Author(s) : Boyu Xue

xueby2019@126.com

Cellular and Molecular Biology, Vol. 66 No. 6: Issue 6

Abstract

Traditional Chinese medicine has made some progress in the study of liver fibrosis, and provides valuable experience for clinical treatment of liver fibrosis. The aim of this study was to investigate the rationality of compatibility use of Salvia miltiorrhiza and Radix astragali on liver fibrosis in rats. For this purpose, the rat model of liver fibrosis was treated with single or different compatibilities of herbals extracts for 4 weeks. Saline and colchicine were set as a negative and positive control, respectively. Liver histopathology, liver function, and expressions of key proteins in the TGF-β/Smad/Wnt pathway were assessed. Results showed that compared with colchicine, herbal extracts showed better ability to reduce deposition of α-SMA and type I collagen, and improve liver function. The effect of R. astragali extracts and 1:1 compound on improving liver fibrosis and liver function was relatively better than other treatment options. The compound groups showed a particularly significant effect on reducing Cyclin D1 expression. It was concluded that the 1:1 compatibility use of S. miltiorrhiza extracts and R. astragali extracts can preferably attenuate liver fibrosis by regulating the expression of TGF-β1 and Cyclin D1.

Keywords

Compatibility of Chinese Medicine Cyclin D1 Liver Fibrosis Radix Astragali Salvia Miltiorrhiza
Cao, T., Lu, Y., Zhu, M., Cheng, J., Ye, B., Fang, N., Cui, Y., Xue, B., Lari Najafi, M., & Kazemi, E. (2020). Effects of Salvia miltiorrhiza and Radix astragali on the TGF-β/Smad/Wnt pathway and the pathological process of liver fibrosis in rats. Cellular and Molecular Biology, 66(6), 46–51. https://doi.org/10.14715/cmb/2020.66.6.9
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