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Vol. 66 No. 7: Issue 7

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A comprehensive review of histopathological findings of infections induced by COVID-19

https://doi.org/10.14715/cmb/2020.66.7.22
Salah Tofik Jalal Balaky
Medical Microbiology Department , College of Health Sciences, Hawler Medical University, Kurdistan Region, Irbil, Iraq
Sahar Mohammed Zaki Abdullah
Medical Microbiology Department , College of Health Sciences, Hawler Medical University, Kurdistan Region, Irbil, Iraq
Markov Alexander
Tyumen State Medical University, Tyumen, Russian Federation
Marwah Suliman Maashi
Medical Laboratory Science Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Ayad F. Alkaim
Chemistry Department, College of Science for Women, University of Babylon, Iraq
Sara shahriyari
Student of Medical Science, School of Medicine, Tehran University of Medical Science, Tehran, Iran
Fariba Tabari
Assistant Professor, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
Elham Kazemi
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Corresponding Author(s) : Fariba Tabari

ftabari@tums.ac.ir

Cellular and Molecular Biology, Vol. 66 No. 7: Issue 7

Abstract

The severe acute respiratory syndrome (SARS)-Coronavirus (CoV2) virus, first identified in Wuhan, China, caused the coronavirus disease 2019 (COVID-19) which soon became a global pandemic, as labelled by the World Health Organization (WHO). The transmission method of the infection is primarily through droplets of various sizes. The SARS-CoV2 virus leads to a severe respiratory illness which in the first place causes the simulation of the acute respiratory syndrome. In order to diagnose of COVID-19 efficiently, samples with infection probability need to be examined through histopathological methods. Survival chances of the infected can remarkably increase if the virus is diagnosed timely by reverse transcription-polymerase chain reaction (RT-PCR) or computed tomography (CT) scan of the chest. One of the destructive effects of COVID-19 is the formation of ground-glass opacity (GGO) in the lungs which might be regarded to be equivalent to high-altitude pulmonary edema (HAPE). COVID-19 acts very similarly to SARS and Middle East Respiratory Syndrome (MERS) which can be inactivated by the chemical compounds of ethanol and sodium hypochlorite. Epidemiologic characteristics of COVID-19 have been indicated by numerous studies; however, there is still a lack of details of pathologic changes in the lung. The present comprehensive review is an attempt to assess and cover the current state of knowledge on COVID-19 disease based on the histopathologic studies conducted before May 2020.

Keywords

COVID-19 Pneumonia Clinical features Biopsy Histopathological changes.
Balaky, S. T. J., Zaki Abdullah, S. M., Alexander, M., Maashi, M. S., Alkaim, A. F., shahriyari, S., Tabari, F., & Kazemi, E. (2020). A comprehensive review of histopathological findings of infections induced by COVID-19. Cellular and Molecular Biology, 66(7), 143–151. https://doi.org/10.14715/cmb/2020.66.7.22
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