Copyright (c) 2023 Jin Yoo, Daeyeol Kim
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.10- or 30-minute treadmill exercise rescues motor behaviors through inhibiting apoptosis in a rat MCAo model
Corresponding Author(s) : Daeyeol Kim
Cellular and Molecular Biology,
Vol. 69 No. 12: New discoveries in gene expression and mutation
Abstract
Ischemic stroke, one of the world’s leading fatal diseases, has a high recurrence and incidence that can lead to severe mortality and disability. In this study, we investigated whether exercise can treat ischemic stroke to prevent recurrence and improve functional impairment. Experimental cerebral ischemia was induced by middle cerebral artery occlusion (MCAo) in rats, and the effect of 10- or 30-minute training for two weeks was evaluated. Following cylinder and rota-rod behavioral tests, we found that motor function was improved compared to the non-exercise group. In addition, the brain infarct volume was decreased after exercise following TTC staining. Further examination of the cell signaling mechanisms involved in the improvement showed that the immune reactivity significantly decreased the expression of the pro-apoptotic protein, Bax, and increased that of the anti-apoptotic protein, Bcl-2. Our results suggest that exercise has a beneficial effect on ischemic stroke for short- or long-term training.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
