Issue

Vol. 62 No. 3: Issue 3

The undersigned hereby assign all rights, included but not limited to copyright, for this manuscript to CMB Association upon its submission for consideration to publication on Cellular and Molecular Biology. The rights assigned include, but are not limited to, the sole and exclusive rights to license, sell, subsequently assign, derive, distribute, display and reproduce this manuscript, in whole or in part, in any format, electronic or otherwise, including those in existence at the time this agreement was signed. The authors hereby warrant that they have not granted or assigned, and shall not grant or assign, the aforementioned rights to any other person, firm, organization, or other entity. All rights are automatically restored to authors if this manuscript is not accepted for publication.

Human colon cancer HT-29 cell death responses to doxorubicin and Morus Alba leaves flavonoid extract

S Fallah
Iran University of Medical Sciences Department of Biochemistry, Faculty of Medicine Tehran Iran
A Karimi
Tehran University of Medical Sciences Department of Biochemistry Tehran Iran
G Panahi
Tehran University of Medical Sciences Department of Biochemistry Tehran Iran
S Gerayesh Nejad
Tehran University of Medical Sciences Department of Biochemistry Tehran Iran
R Fadaei
Iran University of Medical Sciences Department of Biochemistry, Faculty of Medicine Tehran Iran
M Seifi
University of Alberta Department of Medical Genetics, Faculty of Medicine and Dentistry Edmonton Canada

Corresponding Author(s) : S Fallah

fallah.s@iums.ac.ir

Cellular and Molecular Biology, Vol. 62 No. 3: Issue 3

Abstract

The mechanistic basis for the biological properties of Morus alba flavonoid extract (MFE) and chemotherapy drug of doxorubicin on human colon cancer HT-29 cell line death are unknown. The effect of doxorubicin and flavonoid extract on colon cancer HT-29 cell line death and identification of APC gene expression and PARP concentration of HT-29 cell line were investigated. The results showed that flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line. MFE and doxorubicin exert a cytotoxic effect on human colon cancer HT-29 cell line by probably promoting or induction of apoptosis.

Keywords

Cell death Doxorubicin Flavonoid Viability.
Fallah, S., Karimi, A., Panahi, G., Gerayesh Nejad, S., Fadaei, R., & Seifi, M. (2016). Human colon cancer HT-29 cell death responses to doxorubicin and Morus Alba leaves flavonoid extract. Cellular and Molecular Biology, 62(3), 72–77. Retrieved from https://mail.cellmolbiol.org/index.php/CMB/article/view/822
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
Author biographies is not available.
Download this PDF file
PDF
Statistic
Read Counter : 942 Download : 412