DNA Methylation and microRNA patterns are in association with the expression of BRCA1 in ovarian cancer

M Shariati-Kohbanani; M Zare-Bidaki; M M Taghavi; Z Taghipour; A Shabanizadeh; D Kennedy; H Dahim; M R Salahshoor; C Jalili; M Kazemi Arababadi

Issue

Vol. 62 No. 1: Issue 1

Issue Published : January 31, 2016

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DNA Methylation and microRNA patterns are in association with the expression of BRCA1 in ovarian cancer

M Shariati-Kohbanani

Rafsanjan University of Medical Sciences Dept. of Anatomy, Faculty of Medicine Rafsanjan Iran

M Zare-Bidaki

Rafsanjan University of Medical Sciences Immunology of Infectious Diseases Research Center Rafsanjan Iran

M M Taghavi

Rafsanjan University of Medical Sciences Dept. of Anatomy, Faculty of Medicine Rafsanjan Iran

Z Taghipour

Rafsanjan University of Medical Sciences Dept. of Anatomy, Faculty of Medicine Rafsanjan Iran

A Shabanizadeh

Rafsanjan University of Medical Sciences Dept. of Anatomy, Faculty of Medicine Rafsanjan Iran

D Kennedy

Griffith University School of Natural Sciences and Eskitis Institute for Drug Discovery Brisbane Australia

H Dahim

Isfahan University of Medical Sciences School of Pharmacy and Pharmacutical Sciences Isfahan Iran

M R Salahshoor

Kermanshah University of Medical Sciences Fertility and Infertility Research Center Kermanshah Iran

C Jalili

Kermanshah University of Medical Sciences Fertility and Infertility Research Center Kermanshah Iran

M Kazemi Arababadi

Rafsanjan University of Medical Sciences Immunology of Infectious Diseases Research Center Rafsanjan Iran

Corresponding Author(s) : M Shariati-Kohbanani

Cellular and Molecular Biology, Vol. 62 No. 1: Issue 1
Article Published : January 11, 2016

Abstract

Ovarian cancer is the sixth most prevalent cancer in women and is considered the most lethal gynecological malignancy. It can be inherited as a familial disease but also has a strong spontaneous occurrence. Although the disease is associated with genome instability brought on by genetics and environmental factors there is evidence that mutations in the gene encoding for the breast cancer type 1 susceptibility protein (BRCA1) or its down-regulation are involved in its development. Down-regulation of BRCA1 expression by hypermethylation of its promoter may account for some cases of ovarian cancer but this does not explain the cause of the majority of the disease. This review explores the role of BRCA1 promoter hypermethylation and micro-RNAs (miRNA) involved in the regulation of BRCA1 and their role in ovarian cancer development as well as some of the exciting discoveries which could lead to targeting miRNA with a view to restoring BRCA1 expression in diseased tissues.

Keywords

Ovarian cancer BRCA1 Hypermethylation Micro-RNA.

Shariati-Kohbanani, M., Zare-Bidaki, M., Taghavi, M. M., Taghipour, Z., Shabanizadeh, A., Kennedy, D., Dahim, H., Salahshoor, M. R., Jalili, C., & Kazemi Arababadi, M. (2016). DNA Methylation and microRNA patterns are in association with the expression of BRCA1 in ovarian cancer. Cellular and Molecular Biology, 62(1), 16–23. Retrieved from https://mail.cellmolbiol.org/index.php/CMB/article/view/774